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Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
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Restriction-modification systems in lactococcus lactis
Gene, 1995Several restriction-modification (R-M) systems have been identified in Lactococcus lactis. Most of the systems have been plasmid encoded and function as phage-resistance mechanisms. At least five different type-II R-M systems, LlaAI, LlaBI, LlaCI, LlaDI and LlaEI, were identified in isolates from a mixed Cheddar starter culture.
N, Nyengaard +2 more
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Restriction–modification system in bacteriophage MB78
Biochemical and Biophysical Research Communications, 2003Restriction-modification system is present in bacteria to protect the cells against phage infection. Interestingly, the bacteriophage MB78, a virulent phage of Salmonella typhimurium possesses restriction-modification system. Permissive host transformed with plasmid having the genomic fragment of MB78 carrying the putative restriction-modification ...
Deepti, Chaturvedi +1 more
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Selfish Behavior of Restriction-Modification Systems
Science, 1995Plasmids carrying gene pairs encoding type II DNA restriction endonucleases and their cognate modification enzymes were shown to have increased stability in Escherichia coli . The descendants of cells that had lost these genes appeared unable to modify a sufficient number of recognition sites in their chromosomes to
T, Naito, K, Kusano, I, Kobayashi
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The restriction-modification system inStreptomyces flavopersicus
Folia Microbiologica, 2001To clone bifunctional vectors in streptomycetes, it was necessary to define the restriction-modification system of Streptomyces flavopersicus. Plasmid DNA from bifunctional vectors pIJ699 and pXED3-13, isolated from E. coli strains with different methylation systems: E. coli DH5 alpha (dam+ dcm+), E. coli MB5386 (dam dcm), E.
D, Lyutzkanova +2 more
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Restriction-modification systems in Streptomyces antibioticus
Canadian Journal of Microbiology, 1985Several restriction systems were detected in different strains of Streptomyces antibioticus by using actinophages as biological indicators. Adsorption of phages to the bacteria, together with the study of the efficiency of plating gave an initial indication of restriction in three strains.
J, Sànchez +4 more
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Type II restriction—modification systems
Trends in Genetics, 1988Abstract The genes for increasing numbers of type II restriction and modification enzymes are being cloned and characterized. The gene arrangements and enzyme sequences are quite diverse in spite of the biochemical similarities of the enzymes.
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Restriction-modification systems determined by Pseudomonas plasmids
Plasmid, 1982Abstract Four additional Pseudomonas R plasmids determining the Pae R7 restriction-modification system have been detected. All are transfer deficient and appear to belong to the same incompatibility group. The Pseudomonas fertility plasmid FP110 determines a different restriction-modification system and also inhibits the propagation of phage B39
G A, Jacoby, L, Sutton
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Cloned restriction-modification systems — a review
Gene, 1988The genes for numerous restriction endonucleases and modification methylases have been cloned into Escherichia coli. A summary is given for the clones isolated so far (115 entries) and of the procedures used to obtain them.
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