Results 211 to 220 of about 1,405,430 (301)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A Genetic Method for Distinguishing Cryptic <i>Pocillopora</i> Species in French Polynesia Without Sequencing. [PDF]

Ecol Evol
Cohn FM, Johnston EC, Burgess SC, Sims JA, Layagala K, Harnay P, Putnam HM, Correa AMS.   +7 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Direct comparison of serine restriction on the viability of normal and cancer cells demonstrates that methionine restriction is more cancer specific. [PDF]

Front Oncol
Miyashi Y, Ishiguro T, Han Q, Li S, Kang BM, Bouvet M, Tome Y, Nishida K, Hoffman RM.   +8 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Editorial: Host factors involved in viral infection

Frontiers in Microbiology
Jose M. Jimenez-Guardeño, Jose M. Jimenez-Guardeño, Luis Menéndez-Arias, Gilberto Betancor   +3 more
doaj   +1 more source

Defending synthetic DNA orders against intra-order splitting-based obfuscation. [PDF]

Nat Commun
Tayouri-Attia S, Kogan V, Beal J, Levy T, Farbiash D, Flyangolts K, Murphy ST, Mitchell T, Doughty R, Quintana F, Stallings J, Nute M, Godbold GD, Treangen TJ, Rotblat B, Veksler-Lublinsky I, Puzis R.   +16 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Momentary associations between perceived stress, dietary restriction, and eating behaviors in adolescents. [PDF]

J Pediatr Psychol
Liu P, Morales JC, Dunton GF, Mason TB.
europepmc   +1 more source