Results 161 to 170 of about 612,357 (298)

<i>Helicobacter pylori</i> base-excision restriction enzyme in stomach carcinogenesis. [PDF]

PNAS Nexus
Fukuyo M, Takahashi N, Hanada K, Ishikawa K, Venclovas Č, Yahara K, Yonezawa H, Terabayashi T, Katsura Y, Osada N, Kaneda A, Camargo MC, Rabkin CS, Uchiyama I, Osaki T, Kobayashi I.   +15 more
europepmc   +1 more source

A restriction enzyme reduced representation sequencing approach for low-cost, high-throughput metagenome profiling. [PDF]

PLoS One, 2020
Hess MK, Rowe SJ, Van Stijn TC, Henry HM, Hickey SM, Brauning R, McCulloch AF, Hess AS, Kirk MR, Kumar S, Pinares-Patiño C, Kittelmann S, Wood GR, Janssen PH, McEwan JC.   +14 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Modified DNA substrate selectivity by GmrSD-family Type IV restriction enzyme BrxU. [PDF]

Philos Trans R Soc Lond B Biol Sci
Readshaw JJ, Lee YJ, Weigele P, Blower TR.   +3 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Novel triple-target panels utilizing methylation-sensitive restriction enzyme-based quantitative PCR for detecting advanced cervical precancers and cancers among high-risk HPV-positive women. [PDF]

J Transl Med
Chen S, Dai H, Hu S, Gao T, Chen M, Zhou X, Dai L, Zhao X, Zhao F.   +8 more
europepmc   +1 more source

SEVA 3.1: enabling interoperability of DNA assembly among the SEVA, BioBricks and Type IIS restriction enzyme standards. [PDF]

Microb Biotechnol, 2020
Damalas SG, Batianis C, Martin-Pascual M, de Lorenzo V, Martins Dos Santos VAP.   +4 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

A validated restriction enzyme ddPCR cg05575921 (AHRR) assay to accurately assess smoking exposure. [PDF]

Clin Epigenetics
Fitzgerald S, Bhat B, Print C, Jones GT.
europepmc   +1 more source