Results 141 to 150 of about 3,488,118 (356)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Indoor localization and trajectory correction with point cloud-derived backbone map

open access: yesInternational Journal of Applied Earth Observations and Geoinformation
As a commonly used indoor internet-of-things (IoT) positioning method, fingerprinting is frequently carried out through the fusion of inertial and WiFi or magnetic data. Nevertheless, signals like magnetic intensity and WiFi received signal strength tend
Zhenqi Zheng   +6 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

open access: yesFEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Irreducible restrictions of closed mappings

open access: yesTopology and its Applications, 1998
By a result of \textit{N. Lashnev} [Sov. Math., Dokl. 6, 1504-1506 (1966); translation from Dokl. Akad. Nauk SSSR 165, 756-758 (1965; Zbl 0145.19603)], every continuous, closed surjection \(f:X\to Y\), with \(X\) paracompact and \(Y\) Fréchet, is inductively irreducible (i.e., there exists a closed \(X'\subset X\) such that \(f(X')=Y\) and \(f| X'\) is
openaire   +1 more source

Goal-directed therapy: what is the goal again?

open access: yesPerioperative Medicine
Recent attention has focused on intraoperative hypotension (IOH) and hemodynamic instability. This enhanced awareness to limit IOH, combined with fluid restriction and increased vasopressor use, has been associated with an increase in postoperative acute
Amy Yerdon   +5 more
doaj   +1 more source

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