Results 181 to 190 of about 798,636 (312)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Aegilops tauschii genome assembly v6.0 with improved sequence contiguity differentiates assembly errors from genuine differences with the D subgenome of Chinese Spring wheat assembly IWGSC RefSeq v2.1. [PDF]

G3 (Bethesda)
Maratikyathanahalli Srikanta R, Wang L, Zhu T, Deal KR, Huo N, Gu YQ, McGuire PE, Dvorak J, Luo MC.   +8 more
europepmc   +1 more source

Restriction map of the genomic DNA of Lactobacillus casei bacteriophage PL-1 and nucleotide sequence of its cohesive single-stranded ends

, 1994
Yukihiko Nakashima, Hiroya Ikeda, Yukari Kakita, Fumio Miake, Kenji Watanabe   +4 more
openalex   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Genomic characteristics of the multiresistant Acinetobacter baumannii global clone 1 reference strain A297/RUH875. [PDF]

J Antimicrob Chemother
Koong J, Hall RM, Hamidian M.
europepmc   +1 more source

Scaffolding and validation of bacterial genome assemblies using optical restriction maps [PDF]

, 2008
Niranjan Nagarajan, Timothy D. Read, Mihai Pop   +2 more
openalex   +1 more source

Reformulating the Value Restriction and the Not-Strict Value Restriction in Terms of Possibility Preference Map

, 2022
Fujun Hou
openalex   +2 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Brain magnetic resonance imaging findings in hyperammonemic hepatic encephalopathy: A case series and literature review. [PDF]

Biomed Rep
Bakharji A, Alarfaj H, Omar S, Alzahrani S, Alzahrani N, Alahmari F, Al Mulhim S, Almuhaish H, Bashir S, Al-Harbi TM.   +9 more
europepmc   +1 more source

Russel and Rao Coefficient is a Suitable Substitute for Dice Coefficient in Studying Restriction Mapped Genetic Distances of Escherichia coli

, 2023
Zhu En Chay, Chin How Lee, Kun Cheng Lee, Jack SH Oon, Maurice HT Ling   +4 more
openalex   +2 more sources