Results 241 to 250 of about 829,506 (334)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Clinics in diagnostic imaging (224). [PDF]

Singapore Med J
Li J.
europepmc   +1 more source

Cokernels of restriction maps and subgroups of norm one

, 2018
Cristian D. González-Avilés
openalex   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Personalised Nutrition in Obesity and Prediabetes: Do Genotypes Matter? [PDF]

Nutrients
Bossowska M, Bossowski F, Adamska-Patruno E, Maliszewska K, Krętowski A.   +4 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Renal sinus leiomyoma mimicking papillary renal cell carcinoma: A case report. [PDF]

Radiol Case Rep
Ozaki S, Yamamoto T, Unten S, Shimizu R, Yokoyama N, Asai A, Narita A, Okada H, Shimohira M, Kurosu H, Ito T, Suzuki K.   +11 more
europepmc   +1 more source

Temporal Relational Sheaf Graph Attention Networks or Multi-Asset Trading with Higher-Order Cochains and Bayesian Restriction Maps

Andel, Tomasz
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

The Influence of Sleep and Diet on Human Peripheral Immunity and Chronic Health Conditions. [PDF]

Research (Wash D C)
Zhao Y, Li W, Li B, Zhou S, Zhao X, Wang Q, Cheng Y, Luo Y, Han J, Han X, Li H, Gao J, Zhao J, Sun Z, Kong M, Zhou X, Yu Y, Hou W, Chen Q, Zhang J, Wang X, Luo J, Jin L, Shi L, Zheng Y, Human Phenome Project Technological Consortium, Human Phenome Project Scientific Consortium, Tang H, Wang S, Qian F.   +29 more
europepmc   +1 more source