Results 61 to 70 of about 798,636 (312)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Revista Agrogeoambiental, 2022 This work aimed to identify and map the pedological restrictions of the lands in the middle course of the Paraíba River. For this, GIS SPRING, digital soil map, and the Agricultural Zoning of the State of Paraíba information were used.
Paulo Roberto Megna Francisco +4 more
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
BMC Genomics, 2012 Background Sequencing projects using a clone-by-clone approach require the availability of a robust physical map. The SNaPshot technology, based on pair-wise comparisons of restriction fragments sizes, has been used recently to build the first physical ...
Philippe Romain +13 more
doaj +1 more source
A renormalization fixed point for Lorenz maps
, 2010 A Lorenz map is a Poincar\'e map for a three-dimensional Lorenz flow. We describe the theory of renormalization for Lorenz maps with a critical point and prove that a restriction of the renormalization operator acting on such maps has a hyperbolic fixed ...
Björn Winckler +6 more
core +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
On operations on some classes of discontinuous maps
Karpatsʹkì Matematičnì Publìkacìï, 2011 A map $f:Xightarrow Y$ between topological spaces is calledscatteredly continuous (pointwise discontinuous) if for eachnon-empty (closed) subspace $Asubset X$ the restriction $f|_{A}$has a point of continuity.
B. M. Bokalo, N. M. Kolos
doaj
Naturality and definability II
Cubo, 2019 We regard an algebraic construction as a set-theoretically defined map taking structures A to structures B which have A as a distinguished part, in such a way that any isomorphism from A to A' lifts to an isomorphism from B to B'.
Wilfrid Hodges, Saharon Shelah
doaj +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
G3: Genes, Genomes, Genetics, 2017 Developments in next-generation sequencing allow genotyping of thousands of genetic markers across hundreds of individuals in a cost-effective manner. Because of this, it is now possible to rapidly produce dense genetic linkage maps for nonmodel species.
Christopher M. Hollenbeck +5 more
doaj +1 more source