Results 71 to 80 of about 2,788,761 (334)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Is the American Zebu really Bos indicus?

Genetics and Molecular Biology, 1999
The American continent was colonized in the 16th century by Europeans who first introduced cattle of Bos taurus origin. Accounts register introduction of Bos indicus cattle into South America in the 19th and continuing through the 20th century, and most ...
Flávio V. Meirelles, Artur J.M. Rosa, Raysildo B. Lôbo, Joaquim M. Garcia, Lawrence C. Smith, Francisco A.M. Duarte   +5 more
doaj   +3 more sources

Spatio Temporal Analysis of Land Use Change for Supporting Landslide Exposure Assessment

Indonesian Journal of Geography, 2014
Located in landslide prone areas, Cipanas and Pacet sub-districts are placed in areas where land uses are very dynamic. Land use change analysis is needed in these sub-districts for assessing its pattern and the driving factors that caused the change ...
Anung . Kurniawan, B.G.C.M (Bart) Krol
doaj   +1 more source

Some Restrictions on the Maps in Minimal Resolutions

Journal of Algebra, 1998
Let \((A,{\mathfrak m})\) be a Noetherian local ring. The authors prove that there is an integer \(t=t(A)\geq 1\) such that for each finitely generated \(A\)-module \(M\) of infinite projective dimension the ideal generated by the entries of the map \(\varphi_i\) is not contained in \({\mathfrak m}^t\) for all \(i>1+\text{depth} A\), where \[ (F_ ...
Kisuk Lee, Jee Koh
openaire   +3 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Development of a Sequence-Based Reference Physical Map of Pea (Pisum sativum L.)

Frontiers in Plant Science, 2019
Whole genome profiling (WGP) is a sequence-based physical mapping technology and uses sequence tags generated by next generation sequencing for construction of bacterial artificial chromosome (BAC) contigs of complex genomes.
Krishna Kishore Gali, Bunyamin Tar’an, Mohammed-Amin Madoui, Edwin van der Vossen, Jan van Oeveren, Karine Labadie, Helene Berges, Abdelhafid Bendahmane, Reddy V. B. Lachagari, Judith Burstin, Tom Warkentin   +10 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Convexification of restricted Dirichlet-to-Neumann map [PDF]

Journal of Inverse and Ill-posed Problems, 2017
Abstract By our definition, “restricted Dirichlet-to-Neumann (DN) map” means that the Dirichlet and Neumann boundary data for a coefficient inverse problem (CIP) are generated by a point source running along an interval of a straight line. On the other hand, the conventional DN data can be generated, at least sometimes, by a point source
openaire   +4 more sources

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source