Results 101 to 110 of about 2,423,969 (313)

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

The mapping and ordering of fragments of SV40 DNA produced by restriction endonucleases [PDF]

, 1974
K. N. Subramanian, J. Pan, S Zain, S Weissman   +3 more
openalex   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

On soft covering spaces in soft topological spaces

AIMS Mathematics
In this paper, we present the concept of a soft covering map on a soft topological space. We also introduce the notion of a soft local homeomorphism and establish the relationship between soft local homeomorphism and soft open mapping.
Mohammed Abu Saleem
doaj   +1 more source

Optical mapping as a routine tool for bacterial genome sequence finishing

BMC Genomics, 2007
Background In sequencing the genomes of two Xenorhabdus species, we encountered a large number of sequence repeats and assembly anomalies that stalled finishing efforts.
Gaudriault Sophie, Forst Steve, Du Zijin, Darby Creg, Bode Helge B, Barbazuk Brad, Miller Nancy, Henkhaus John, Goldman Barry S, Norton Stacie, Latreille Phil, Goodner Brad, Goodrich-Blair Heidi, Slater Steven   +13 more
doaj   +1 more source

Specific Cleavage and Physical Mapping of Simian-Virus-40 DNA by the Restriction Endonuclease of Arthrobacter luteus [PDF]

, 1976
Robert Yang, A. Van de Voorde, Walter Fiers   +2 more
openalex   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Fock spaces corresponding to positive definite linear transformations

, 2003
Suppose $A$ is a positive real linear transformation on a finite dimensional complex inner product space $V$. The reproducing kernel for the Fock space of square integrable holomorphic functions on $V$ relative to the Gaussian measure $d\mu_A(z)=\frac ...
Fabec, R., Olafsson, G., Sengupta, A.
core   +1 more source

Mapping the Trypanosoma cruzi Genome: Analyses of Representative Cosmid Libraries

BioTechniques, 1996
In order to generate contiguous cosmid coverage of the genome of the protozoan parasite Trypanosoma cruzi for large-scale sequence analysis, a cosmid library of 36864 individual, primary clones was generated.
J. Hanke, D.O. Sánchez, J. Henriksson, L. Åslund, U. Pettersson, A.C.C. Frasch, J.D. Hoheisel   +6 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source