Rapid Mapping and Identification of Mutations inCaenorhabditis elegansby Restriction Site-Associated DNA Mapping and Genomic Interval Pull-Down Sequencing [PDF]
Sean M. O’Rourke +11 more
openalex +1 more source
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Gametocidal genes: biological mechanisms owing to hybrid dysgenesis in crop breeding, challenges and innovation. [PDF]
Walter N, King I, King J, Grewal S.
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
An anchored restriction-mapping approach applied to the genetic analysis of the Anopheles gambiae malaria vector complex 1. [PDF]
Kostas D. Mathiopoulos +2 more
openalex +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
InSillyClo, a User-Friendly Web Application to Assist Large-Scale Golden Gate Cloning and MoClo Workflows. [PDF]
Galez H +5 more
europepmc +1 more source
Problem‐solving test: Restriction endonuclease mapping [PDF]
openaire +2 more sources

