Results 121 to 130 of about 1,057,154 (313)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Testable Restrictions of General Equilibrium Theory in Exchange Economies with Externalities [PDF]

open access: yes
The theory of general equilibrium was criticized for its apparent lack of testable implications,as seemingly implied by the results of Sonnenschein, Mantel and Debreu in the Seventies.
Andrés Carvajal
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

A Priori Inequality Restrictions and Bound Analysis in VAR Models [PDF]

open access: yes
The aim of this paper is to use inequality restrictions on the parameters of a structural model to find bounds on impulse response functions which are valid for any structural representation satisfying those restrictions.
Massimo Franchi
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Testable Restrictions of Nash Equilibrium in Games with Continuous Domains [PDF]

open access: yes
This paper studies the falsiability of the hypothesis of Nash behavoir, for the case of a finite number of players who choose from continuous domains, subject to constraints. The results obtained here are negative. Assuming the observation of finite data
Andrés Carvajal
core  

Fourier Restriction: From Linear Restriction to Multilinear Restriction

open access: yes
This dissertation studies the Fourier restriction, which is to find the range of the constants p, q such that the L^q norm on a chosen subset of the Fourier domain is bounded above by the L^p norm in a spacial domain, up to some constant that is independent of the function.
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

The welfare costs of urban outdoor water restrictions

open access: yes
Outdoor water restrictions are usually implemented as bans on a particular type of watering technology (sprinklers), which allow households to substitute for labour-intensive (hand-held) watering. This paper presents a household production model approach
Ingram, Gordon   +2 more
core  

Interest-Bearing Currency and Legal Restrictions Theory: Lessons from the Southern Confederacy [PDF]

open access: yes
Instances of interest-bearing currency are relatively rare. The Southern Confederacy issued both interest and non-interest-bearing notes during the Civil War.
Marc D. Weidenmier   +1 more
core  

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