Results 251 to 260 of about 1,057,154 (313)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Associations between state-level abortion restrictions and postpartum depression symptoms from a United States nationwide cohort. [PDF]

Lancet Reg Health Am
Haas-Kogan ME, Pelletier A, Koire A, Spagnolo PA, Bartz D.   +4 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Impact of the COVID-19 pandemic on obesity: a prospective cohort study of the Canadian Longitudinal Study on Aging (CLSA). [PDF]

BMJ Open
Sakib MN, Griffith LE, Erbas Oz U, Basta NE, Gerstein HC, Morgenstern JD, Kirkland S, Thabane L, Smith BT, Balion C, McMillan JM, Raina P, Anderson LN.   +12 more
europepmc   +1 more source

Political Beliefs and Legitimacy of Government Restrictions During the COVID-19 Pandemic. [PDF]

Behav Sci (Basel)
Palace M, Madan M, May B, Smith L, Daly S, Terbeck S, Jacobson T.   +6 more
europepmc   +1 more source

Planning For Unmet Social Needs In Pandemics: Teachers' Experiences Of Unacknowledged Care Work. [PDF]

Public Health Ethics
Williams J, Hooker C, Gilbert GL, Hor S, Donovan L, Degeling C.   +5 more
europepmc   +1 more source

Regulatory policies for online alcohol access control: a comparative scoping review of international approaches. [PDF]

Korean J Fam Med
Sungkhabut W, Saiprom K, Ayudhya CDN, Viboonsanti S, Vatcharavongvan P.   +4 more
europepmc   +1 more source

From Control to Care: Reframing Medication Access Policies Through Public Health Ethics. [PDF]

J Law Med Ethics
Jaffe K, Evans EA.
europepmc   +1 more source

Trajectories of internalizing problems during and after the COVID-19 pandemic: The effects of sex and early life stress. [PDF]

J Affect Disord
Buthmann JL, Uy JP, Rocha SE, Antonacci CA, Gotlib IH.   +4 more
europepmc   +1 more source