Results 31 to 40 of about 2,233 (156)

Connective Tissue Growth Factor Is Overexpressed in Explant Lung Tissue and Broncho-Alveolar Lavage in Transplant-Related Pulmonary Fibrosis

Frontiers in Immunology, 2021
BackgroundConnective tissue growth factor (CTGF) is an important mediator in several fibrotic diseases, including lung fibrosis. We investigated CTGF-expression in chronic lung allograft dysfunction (CLAD) and pulmonary graft-versus-host disease (GVHD ...
Arno Vanstapel, Arno Vanstapel, Roel Goldschmeding, Roel Broekhuizen, Tri Nguyen, Annelore Sacreas, Janne Kaes, Tobias Heigl, Stijn E. Verleden, Alexandra De Zutter, Geert Verleden, Geert Verleden, Birgit Weynand, Birgit Weynand, Erik Verbeken, Erik Verbeken, Laurens J. Ceulemans, Laurens J. Ceulemans, Dirk E. Van Raemdonck, Dirk E. Van Raemdonck, Arne P. Neyrinck, Arne P. Neyrinck, Helene M. Schoemans, Bart M. Vanaudenaerde, Robin Vos, Robin Vos   +25 more
doaj   +1 more source

Immune Checkpoints Expression in Chronic Lung Allograft Rejection

Frontiers in Immunology, 2021
Chronic lung allograft dysfunction (CLAD) is the main cause of poor survival and low quality of life of lung transplanted patients. Several studies have addressed the role of dendritic cells, macrophages, T cells, donor specific as well as anti-HLA ...
Ilaria Righi, Valentina Vaira, Valentina Vaira, Letizia Corinna Morlacchi, Giorgio Alberto Croci, Giorgio Alberto Croci, Valeria Rossetti, Francesco Blasi, Francesco Blasi, Stefano Ferrero, Stefano Ferrero, Mario Nosotti, Mario Nosotti, Lorenzo Rosso, Lorenzo Rosso, Mario Clerici, Mario Clerici   +16 more
doaj   +1 more source

Twelve-month effects of everolimus on renal and lung function in lung transplantation: differences in chronic lung allograft dysfunction phenotypes

Therapeutic Advances in Chronic Disease, 2021
Background: Chronic lung allograft dysfunction (CLAD), a complication affecting the survival of lung transplanted patients, includes two clinical phenotypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS).
Filippo Patrucco, Elias Allara, Massimo Boffini, Mauro Rinaldi, Cristina Costa, Carlo Albera, Paolo Solidoro   +6 more
doaj   +1 more source

COMP: A Potential Early Biomarker of RAS After Lung Transplantation

Transplantation Direct, 2021
Background. Chronic rejection, defined as chronic lung allograft dysfunction (CLAD), is the major factor limiting long-term survival after lung transplantation (LTx). A specific subgroup of CLAD is restrictive allograft syndrome (RAS).
Mirza Novo, MD, Johan Westin, MD, PhD, Lars-Magnus Andersson, MD, PhD, Anton Jonsson Berdenius, MSc, Rickard Nordén, PhD, Jesper M. Magnusson, MD, PhD   +5 more
doaj   +1 more source

Successful heart transplantation following melphalan plus dexamethasone therapy in systemic AL amyloidosis

Haematologica, 2008
Recurrence in the allograft and progression in other organs increase mortality after cardiac transplantation in AL amyloidosis. Survival may be improved after suppression of monoclonal light chain (LC) production following high dose melphalan and ...
Aude Mignot, Frank Bridoux, Antoine Thierry, Shaida Varnous, Myriam Pujo, Annick Delcourt, Jean Marc Gombert, Jean-Michel Goujon, Fréderic Favreau, Guy Touchard, Daniel Herpin, Arnaud Jaccard   +11 more
doaj   +1 more source

Characterization of chronic lung allograft dysfunction phenotypes using spectral and intrabreath oscillometry

Frontiers in Physiology, 2022
Background: Chronic lung allograft dysfunction (CLAD) is the major cause of death beyond 2 years after lung transplantation and develops in 50% of all patients by 5 years post-transplant.
Anne Fu, Anastasiia Vasileva, Nour Hanafi, Natalia Belousova, Natalia Belousova, Joyce Wu, Joyce Wu, Sarada Sriya Rajyam, Clodagh M. Ryan, Clodagh M. Ryan, Zoltán Hantos, Chung-Wai Chow, Chung-Wai Chow, Chung-Wai Chow   +13 more
doaj   +1 more source

Disease progression in patients with the restrictive and mixed phenotype of Chronic Lung Allograft dysfunction-A retrospective analysis in five European centers to assess the feasibility of a therapeutic trial.

PLoS ONE, 2021
BackgroundChronic Lung Allograft Dysfunction (CLAD) is a major obstacle for long term survival after lung transplantation (LTx). Besides Bronchiolitis Obliterans Syndrome, two other phenotypes of CLAD, restrictive allograft syndrome (RAS) and mixed ...
Jens Gottlieb, Geert M Verleden, Michael Perchl, Christina Valtin, Alexander Vallee, Olivier Brugière, Carlos Bravo   +6 more
doaj   +1 more source

Humoral immune responses mediate the development of a restrictive phenotype of chronic lung allograft dysfunction

JCI Insight, 2020
Understanding the distinct pathogenic mechanisms that culminate in allograft fibrosis and chronic graft failure is key in improving outcomes after solid organ transplantation.
Keizo Misumi, David S. Wheeler, Yoshiro Aoki, Michael P. Combs, Russell R. Braeuer, Ryuji Higashikubo, Wenjun Li, Daniel Kreisel, Ragini Vittal, Jeffrey Myers, Amir Lagstein, Natalie M. Walker, Carol F. Farver, Vibha N. Lama   +13 more
doaj   +1 more source

Early chest CT abnormalities to predict the subsequent occurrence of chronic lung allograft dysfunction

Insights into Imaging, 2023
Introduction Chronic lung allograft dysfunction (CLAD) can take two forms: bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS).
Paul Habert, Elsa Chetrit, Benjamin Coiffard, Fabienne Bregeon, Pascal Thomas, Anderson Loundou, Julien Bermudez, Martine Reynaud-Gaubert, Jean-Yves Gaubert   +8 more
doaj   +1 more source

Cessation of extracorporeal photopheresis in chronic lung allograft dysfunction: effects on clinical outcome in adults

Swiss Medical Weekly, 2017
BACKGROUND Extracorporeal photopheresis (ECP) has been reported to be safe and the ultimate treatment option in lung transplant recipients with chronic lung allograft dysfunction (CLAD), the main overall cause of mortality in lung transplant ...
Cécile Robinson, Lars C Huber, Christian Murer, Macé M. Schuurmans, Malcolm Kohler, Günther F Hofbauer, Christian Benden   +6 more
doaj   +1 more source