Results 71 to 80 of about 2,233 (156)

The Scientific Case for Animal Models: A Perspective From Musculoskeletal Researchers

FASEB BioAdvances, Volume 8, Issue 2, February 2026.
ABSTRACT The National Institutes of Health (NIH) has launched a major initiative to expand human‐based New Approach Methodologies (NAMs) in biomedical research and reduce reliance on animal models. While NAMs offer powerful complementary tools, animal‐based research remains indispensable in musculoskeletal science for understanding complex cellular and
Michael Hadjiargyrou, Blake E. Hildreth III, Frank Ko, Uma Sankar, Tao Yang   +4 more
wiley   +1 more source

Forced Vital Capacity for Defining Restrictive Allograft Syndrome and Mixed Phenotype in Lung Transplant Recipients

The Journal of Heart and Lung Transplantation, 2020
Purpose Chronic Lung Allograft Dysfunction (CLAD) is a heterogeneous disease. Three major phenotypes: bronchiolitis obliterans syndrome (BOS), restrictive allograft syndrome (RAS) and mixed phenotype, are defined based on combinations of lung physiology and chest imaging.
L. Levy, E. Huszti, G. Berra, B. Renaud-Picard, M. Kawashima, A. Takahagi, S. Moshkelgosha, R. Ghany, C. Chow, S. Keshavjee, L. Singer, J. Tikkanen, T. Martinu   +12 more
openaire   +1 more source

The pleural mesothelium and transforming growth factor-β1 pathways in restrictive allograft syndrome: A pre-clinical investigation [PDF]

, 2019
Annelore Sacreas, Jan H. von der Thüsen, Thierry van den Bosch, Birgit Weynand, Erik Verbeken, Charlotte Debbaut, Dirk Van Raemdonck, Robin Vos, Stijn E. Verleden   +8 more
openalex   +1 more source

Restrictive Allograft Syndrome (RAS) in Lung Transplant Recipients Carries Uncertain Additional Prognostic Significance as Compared To BOS [PDF]

, 2014
H.L. Schultz, Claus Andersen, Daniel A. Steinbrüchel, N. H. Bjarnason, Michael Perch, Jørn Carlsen, Martin Iversen   +6 more
openalex   +1 more source

Insufficient Post-Transplant Immunosuppression Induces Restrictive Allograft Syndrome-Like Fibrosis in the Pleura and Lung Parenchyma After Lung Transplantation [PDF]

, 2016
Ei Miyamoto, Masaaki Sato, Hideki Motoyama, Akihiro Aoyama, Toshi Menju, Kei Shikuma, Terumasa Sowa, Maki Saito, Akihiro Takahagi, Satona Tanaka, Masayo Takahashi, Keiji Ohata, Tadakazu Kondo, Kyoko Hijiya, Toyofumi F. Chen‐Yoshikawa, Tatsuya Sato, Makoto Sonobe, Hiroshi Date   +17 more
openalex   +1 more source

Aberrant and Ectopic Cell Populations of the Fibrotic Pushing Border in Restrictive Allograft Syndrome after Lung Transplantation [PDF]

Lena Maureen Leiber, Leonard Christian, Lavinia Neubert, Jannik Ruwisch, Hande Yilmaz, Edith Plucinski, Linus Langer, Jan C. Kamp, Mark Greer, Bernd Haermeyer, Mark Kühnel, Christopher Werlein, A. Justet, Anke K. Bergmann, Matthias Ballmaier, J. Salman, Lars Knudsen, Ulrich Martin, Bart Vanaudenaerde, Ali Önder Yildirim, F. Ius, Florian Laenger, Tobias Welte, Christine S. Falk, Naftali Kaminski, Danny Jonigk, Jens Gottlieb, Jonas C. Schupp   +27 more
openalex   +1 more source

Lower Limit of Normal of Pulmonary Function to Define Baseline Lung Allograft Dysfunction. [PDF]

Transplant Direct
Gerckens M, Simon S, Mümmler C, Arnold P, Barton J, Yildirim AÖ, Behr J, Kneidinger N, Gottlieb J.   +8 more
europepmc   +1 more source

Abnormal spirometry 1 year after lung transplantation may identify patients at risk for chronic lung allograft dysfunction in a multicenter cohort. [PDF]

JHLT Open
Graham AR, Grau-Sepulveda MV, Todd JL, Neely ML, Snyder LD.   +4 more
europepmc   +1 more source

The pleural mesothelium and TGF-β1 pathways in restrictive allograft syndrome : a pre-clinical investigation

, 2019
BACKGROUND: Chronic lung allograft dysfunction (CLAD) hampers long-term survival after lung transplantation. Common fibrosis-related mechanisms in idiopathic pulmonary fibrosis and CLAD instigated the consideration of investigating the differential regulation of pleural mesothelium and transforming growth factor-beta(1) (TGF-beta(1)) in restrictive ...
Sacreas, Annelore, H. von der Thüsen, Jan, P. P. van den Bosch, Thierry, Weynand, Birgit, K. Verbeken, Erik, Debbaut, Charlotte, E. Van Raemdonck, Dirk, Vos, Robin, E. Verleden, Stijn   +8 more
openaire   +1 more source

Respiratory oscillometry in monitoring lung transplant allograft function: a systematic scoping review. [PDF]

Eur Respir Rev
Olanipekun T, Divo M, Abe T, Taddesse A, Poli S, Jacob S, Sheikh A, Sharma N.   +7 more
europepmc   +1 more source