Results 71 to 80 of about 570,477 (309)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

[Restrictive cardiomyopathy].

Herz, 2006
The group of restrictive cardiomyopathies (RKMP) includes a number of myocardial and endomyocardial diseases. These entities are characterized by stiffening of both ventricles resulting in a deterioration of ventricular filling and severe diastolic dysfunction. Systolic ventricular function is usually normal or only mildly impaired.
Wachter, R. Rolf, Pieske, Burkert M.
openaire   +2 more sources

Missense Mutations in the FLNC Gene Causing Familial Restrictive Cardiomyopathy.

Circulation Genomic and Precision Medicine, 2019
Circ Genom Precis Med. 2019;12:e002388. DOI: 10.1161/CIRCGEN.118.002388 March 2019 Alvaro Roldán-Sevilla, MD Julian Palomino-Doza, MD, PhD Javier de Juan, MD Violeta Sánchez, MD Cristina DomínguezGonzález, MD Rafael Salguero-Bodes, MD Fernando ...
Álvaro Roldan-Sevilla, J. Palomino-Doza, J. D. de Juan, V. Sánchez, C. Domínguez-gonzález, R. Salguero-Bodes, F. Arribas-Ynsaurriaga   +6 more
semanticscholar   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Generation of human induced pluripotent stem cell line from a patient with restrictive cardiomyopathy

Stem Cell Research
Restrictive cardiomyopathy (RCM) is a rare cardiomyopathy characterized by diastolic dysfunction, which affects cardiac systolic function. We successfully established human induced pluripotent stem cells (hiPSCs) from peripheral blood mononuclear cells ...
Jingxian Li, Jinxiu Jiang, Lingqun Ye, Zhipeng Lian, Hui Gong, Wei Lei, Yuxiang Dai, Shijun Hu   +7 more
doaj   +1 more source

Pathobiology of cardiomyopathies: Experience at a Tertiary Care Center

Journal of the Practice of Cardiovascular Sciences, 2015
Background: Cardiomyopathies are a heterogeneous group of diseases of the myocardium associated with varied pathology. Pathology data from India are scarce.
Uma Nahar Saikia, Ajay Bahl, Baijayantimala Mishra, Mrinalini Sharma, Vandana Kumari, K K Talwar   +5 more
doaj   +1 more source

Allele-specific silencing ameliorates restrictive cardiomyopathy due to a human myosin regulatory light chain mutation

bioRxiv, 2019
Background Restrictive cardiomyopathy (RCM) is a rare heart disease associated with mutations in sarcomeric genes and with phenotypic overlap with hypertrophic cardiomyopathy. There is no approved therapy. Here, we explore the potential of an interfering
K. Zaleta-Rivera, Alexandra Dainis, A. Ribeiro, P. Cordero, Gabriel Rubio, Ching Shang, Jing Liu, Thomas Finsterbach, V. Parikh, Shirley C. Sutton, Kinya Seo, Nikita Sinha, Nikhil A. Jain, Yong Huang, R. Hajjar, M. Kay, Danuta Szczesna‐Cordary, B. Pruitt, M. Wheeler, E. Ashley   +19 more
semanticscholar   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Restrictive cardiomyopathy. Presentation of seven cases

Acta Pediátrica de México, 2014
Restrictive cardiomyopathy is a disease characterized by diastolic ventricular failure with increase in telediastolic pressure and systolic function preserved.
Luis Alfonso Fonseca Sánchez, Laura Camacho Reyes, Alfredo Bobadilla Aguirre   +2 more
doaj   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source