Results 131 to 140 of about 6,225 (309)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

A lexical-constructional approach to light and sound emission verbs [PDF]

, 2011
Este artículo presenta un detallado análisis léxico-construccional de las clases verbales de emisión de luz y sonido (por ej. destellar, retumbar). El presente trabajo estudia la integración de estas clases verbales en la alternancia causativa-incoativa,
Rosca, Andreea
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Explaining pretrained language models' understanding of linguistic structures using construction grammar. [PDF]

Front Artif Intell, 2023
Weissweiler L, Hofmann V, Köksal A, Schütze H.   +3 more
europepmc   +1 more source

The acquisition of middles and unaccusatives by Cantonese ESL learners. [PDF]

, 1998
by Chan Mable.Thesis submitted in 1997.Thesis (M.Phil.)--Chinese University of Hong Kong, 1998.Includes bibliographical references (leaves 120-124).Abstract also in Chinese.Chapter Chapter1 --- Second Language Acquisition Research: Background to the ...

core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Using Extra-Linguistic Material for Mandarin-French Verbal Constructions Comparison [PDF]

, 2009
International audienceSystematic cross-linguistic studies of verbs syntactic-semantic behaviors for ty-pologically distant languages such as Mandarin Chinese and French are difficult to conduct.Such studies are nevertheless necessary due to the crucial ...
Cheung, Hintat, Desalle, Yann, Gaume, Bruno, Magistry, Pierre, Prevot, Laurent, Shiao, C.Y   +5 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Modifying (the grammar of) adjuncts : an introduction [PDF]

, 2003
One aspect of the progress being made is that the focus of attention has widened. Adverbials, though still the heart of the matter, now form part of a much larger set of constituent types subsumed under the general syntactic label of adjunct; while ...
Fabricius-Hansen, Cathrine, Lang, Ewald, Maienborn, Claudia   +2 more
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source