Results 121 to 130 of about 2,423 (212)

Je dood vervelen of je te pletter amuseren? Het intensiverende gebruik van de pseudoreflexieve resultatiefconstructie in hedendaags Belgisch en Nederlands Nederlands [PDF]

open access: yes, 2016
This paper focuses on the intensifying use of the fake reflexive resultative construction, as demonstrated in the example Hij lacht zich een breuk om die mop (lit. ‘He laughs himself a fracture because of that joke’).
Colleman, Timothy, Gyselinck, Emmeline
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

ケッカク ト ケイロ ヒョウゲン ノ ニンカ ジョウケン ニツイテ [PDF]

open access: yes, 2004
はじめに(抄) 本稿の目的は,run, walk, hobbleなどの移動様態 (manner of motion) を表す非能格動詞(unergative verbs) を語彙的な再帰動詞と分析し,さらに,これらがとる到達点 (goal) を表すPP-経路 (Path) 項- が結果句 (resultatives) とは統語的資格が異なると仮定し、この類の動詞がとる補部 ...
丸田 忠雄
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Speaking of death. [PDF]

open access: yesPhilos Trans R Soc Lond B Biol Sci, 2018
Husband EM.
europepmc   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

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