Results 41 to 50 of about 243,386 (301)

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

The effect of real-time CPR feedback and post event debriefing on patient and processes focused outcomes : a cohort study : trial protocol [PDF]

, 2011
Background: Cardiac arrest affects 30-35, 000 hospitalised patients in the UK every year. For these patients to be given the best chance of survival, high quality cardiopulmonary resuscitation (CPR) must be delivered, however the quality of CPR in real ...
Gao, F., Matthew W Cooke, Davies Robin P, Cooke, MW, Abella, B, Cooke, Matthew (Professor of clinical systems design), Ben Abella, Stallard, Nigel, Nigel Stallard, Stallard Nigel, Perkins, Gavin D., Stallard, N, Gao Smith, Fang; id_orcid, Fang Gao, Quinton, S, Davies, RP, Cooke Matthew W, Gao Fang, Woolley Sarah, Woolley, S, Gao, Fang, Davies, Robin P., Robin P Davies, Abella Ben, Sarah Woolley, Perkins, Gavin, Abella, Ben, Woolley, Sarah, Cooke, Matthew W, Sarah Quinton, Abella, Benjamin S., null null, Gavin D Perkins, Perkins, Gavin D, Smith, F. Gao (Fang Gao), Quinton Sarah, Davies, Robin P, Quinton, Sarah, Perkins Gavin D   +38 more
core   +2 more sources

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Dexmedetomidine for transcatheter aortic valve implantation. Does it protect against acute kidney injury? [PDF]

Revista Chilena de Anestesia, 2023
Guerrero Orriach J.L., Romero Molina S., Sepúlveda Haro E., Bueno García, Ortega Alcántara E.J., Cruz Mañas J.   +5 more
doaj   +1 more source

Level of Pain and Analgesics Taken after Cesarean Section and Differences According to Type of Anesthesia and Demographic Factors

Acta Clinica Croatica, 2022
The aim of this study was to investigate the level of pain and analgesic consumption in puerperas after cesarean section according to the type of anesthesia administered.
Igor Andrić, Dajana Vladić-Spaić, Zoran Karlović, Ana Milas, Boris Matić, Slavica Šimić, Mirko Mihalj   +6 more
doaj   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Use of neuromuscular blocking agents in obstetric anesthesiology: a comprehensive literature review [PDF]

Pediatric Anesthesia and Critical Care Journal (PACCJ)
The use of neuromuscular blocking agents (NMBAs) in obstetric anesthesiology plays a pivotal role in airway management during surgical interventions, particularly cesarean section under general anesthesia.
C. Pellegrino, S. Sorrenti, M. Ciuffreda, E. Pisello, L. Brugiaferri, C. Piangatelli, D. Galante   +6 more
doaj   +1 more source

Outline of the 2005 European Resuscitation Council Guidelines [PDF]

, 2005
Resuscitation guidelines are revised and updated about every 5 years and this happens because resuscitation science continues to advance and clinical guidelines must be updated regularly to reflect these developments and advise healthcare providers ...
Tabone, Diane, Cassar, Mary Rose
core  

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source