Results 111 to 120 of about 86,169 (304)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Pellet resuspension v1

, 2015
For use in Viral and bacterial isolates, propagation and preparation of stocks.
openaire   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Multi-scale numerical simulation of storm-driven sediment transport, resuspension and dispersal dynamics

Environmental Research Communications
Focusing on the scale-dependent sediment redistribution process driven by storm flow control conversion and terrain constraints during extreme storm surge, this study constructs a multi-scale three-dimensional storm surge-sediment coupling model to ...
Chunlei Wei, Peng Zhou, Xiaona Yin, Di Wu, Yaquan Li, Wenhu Zhang   +5 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Resuspension of Threat Agents from Paved Surfaces and Recommended Resuspension Factors — Field Experiments with Pedestrian or Personnel Activity and Vehicles

Resuspension of hazardous particles from paved surfaces poses significant risks during radiological contamination scenarios. Accurate modeling of particle resuspension dynamics is essential for developing effective mitigation strategies and ensuring ...
Hannah Jaglinski, Nico Daiyega, Michael D.R. Kaminski   +2 more
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Sediment dynamics in the Bohai Sea under extreme weather: advances and prospects

Shui kexue jinzhan
Extreme weather events are major drivers of coastal geomorphic change，and understanding the mechanisms governing sediment-dynamic responses to these events is important for resilience-oriented coastal management.
Zhangyi ZHAO, Chenghao WANG, Lin XIE, Huaiyuan LI, Hualiang XIE, Zhiqiang HOU, Yanjie WEI   +6 more
doaj   +1 more source

The effect of sediment resuspension on pelagic nitrogen fixation in a Danish fjord - Sediment characteristics

This dataset contains sediment characteristics relevant to assessing the potential impact of sediment resuspension on biogeochemical processes in a microtidal fjord system.
Attard, Karl Michael, Löscher, Carolin Regina, Schlangen, Isabell, Sørensen, Lisbeth Fürst, Riemann, Lasse   +4 more
core   +1 more source