Results 31 to 40 of about 53,193 (289)

Mechanistic insight into RET kinase inhibitors targeting the DFG-out conformation in RET-rearranged cancer [PDF]

, 2017
Oncogenic fusion events have been identified in a broad range of tumors. Among them, RET rearrangements represent distinct and potentially druggable targets that are recurrently found in lung adenocarcinomas.
Andreas H. Scheel, André Richters, Borrello, Carina Lorenz, Daniel Schütte, Dennis Plenker, Florian Mrugalla, Frauke Leenders, Frett, Gautschi, Georg Pall, Gozgit, Heil, Joachim Diebold, Johannes Brägelmann, Johannes M. Heuckmann, Julian Engel, Justina Stark, Jürgen Wolf, Kevan M. Shokat, Kris Gevaert, Maarten Aerts, Marcel A. Dammert, Marina Keul, Martin L. Sos, Martin Peifer, Maximilian Riedel, Mike Bührmann, Mrugalla, Neil Q. McDonald, Oliver Gautschi, Oliver Pagel, Phillip P. Knowles, Rakhee Chauhan, Reinhard Buettner, René P. Zahedi, Roman K. Thomas, Sigalov, Song, Stefan M. Kast, Verena Tischler, Yang, Yannic Alber, Yanrui Song, Yoh   +44 more
core   +1 more source

Response to Pralsetinib Observed in Meningeal-Metastatic EGFR-Mutant NSCLC With Acquired RET Fusion: A Brief Report

JTO Clinical and Research Reports, 2022
Introduction: RET is well known as an important driver gene in NSCLC. Moreover, RET is a rare acquired resistance mechanism to EGFR-mutant NSCLC. Only 36 NSCLC cases of coexistence of EGFR and RET were reported previously worldwide.
Zichen Zhao, MD, Chao Su, PhD, Weigang Xiu, MD, Weiya Wang, MD, Shasha Zeng, MD, Meijuan Huang, MD, Youling Gong, MD, You Lu, MD, PhD, Yan Zhang, MD, PhD   +8 more
doaj   +1 more source

A secondary RET mutation in the activation loop conferring resistance to vandetanib [PDF]

, 2018
Resistance to vandetanib, a type I RET kinase inhibitor, developed in a patient with metastatic lung adenocarcinoma harboring a CCDC6-RET fusion that initially exhibited a response to treatment. The resistant tumor acquired a secondary mutation resulting
A Drilon, AE Drilon, AT Shaw, B Cosci, B Hess, B Hess, B Pasche, CH Yun, CI Bayly, D Plenker, DR Camidge, G Bussi, G Manning, H Bando, H Fujitani, HJC Berendsen, I Plaza-Menacho, J Goto, J Wang, JB Brown, K Lindorff-Larsen, K Yoh, KL Meagher, L Sutto, LM Mulligan, M Araki, M Parrinello, MW Schmidt, P Emsley, PD Adams, PP Knowles, PP Knowles, T Darden, T Kohno, T Mizukami, WL Jorgensen, YL Choi, YM Koyama   +37 more
core   +5 more sources

Characteristics and outcomes of patients with RET-fusion positive non-small lung cancer in real-world practice in the United States

BMC Cancer, 2021
Background Contradictory and limited data are available about the presentation and outcomes of patients with RET-fusion positive metastatic NSCLC as compared to patients without RET fusions.
Lisa M. Hess, Yimei Han, Yajun Emily Zhu, Naleen Raj Bhandari, Anthony Sireci   +4 more
doaj   +1 more source

Dublin City University at CLEF 2004: experiments in monolingual, bilingual and multilingual retrieval [PDF]

, 2005
The Dublin City University group participated in the monolingual, bilingual and multilingual retrieval tasks this year. The main focus of our investigation this year was extending our retrieval system to document languages other than English, and ...
Burke, Michael, Jones, Gareth J.F., Judge, John, Khasin, Anna, Lam-Adesina, Adenike M., Wagner, Joachim   +5 more
core   +1 more source

Genomic landscape of 891 RET fusions detected across diverse solid tumor types

npj Precision Oncology, 2023
In this study, we report the clinicopathologic and genomic profiles of 891 patients with RET fusion driven advanced solid tumors. All patient samples were tested using a tissue-based DNA hybrid capture next generation sequencing (NGS) assay and a subset ...
Vamsi Parimi, Khaled Tolba, Natalie Danziger, Zheng Kuang, Daokun Sun, Douglas I. Lin, Matthew C. Hiemenz, Alexa B. Schrock, Jeffrey S. Ross, Geoffrey R. Oxnard, Richard S. P. Huang   +10 more
doaj   +1 more source

Evaluating Cache Coherent Shared Virtual Memory for Heterogeneous Multicore Chips [PDF]

, 2013
The trend in industry is towards heterogeneous multicore processors (HMCs), including chips with CPUs and massively-threaded throughput-oriented processors (MTTOPs) such as GPUs.
Hechtman, Blake A., Sorin, Daniel J.
core   +2 more sources

Research Progress on RET Fusion in Non-Small-Cell Lung Cancer

Frontiers in Oncology, 2022
Great progress has been made in the treatment of driver gene-positive Non- Small Cell Lung Cancer (NSCLC) in recent years. RET fusion was seen in 0.7% to 2% of NSCLC and was associated with younger age and never-smoker status.
Lu Zhao, Lu Zhao, Qingyun Mei, Qingyun Mei, Yongchao Yu, Yongchao Yu, Na Wang, Na Wang, Dou Zhang, Dou Zhang, Dongying Liao, Dongying Liao, Jinhui Zuo, Jinhui Zuo, Hongxia Xie, Hongxia Xie, Yingjie Jia, Yingjie Jia, Fanming Kong, Fanming Kong   +19 more
doaj   +1 more source

The relationship between genetic characteristics and clinical characteristics and the efficacy of 131I therapy in children and adolescents with locally advanced or metastatic differentiated thyroid cancer [PDF]

Zhongguo aizheng zazhi, 2022
Background and purpose: The molecular characteristics of differentiated thyroid cancer (DTC) in children and adolescents and its role in clinical practice remain unclear.
SUN Di, SUN Yuqing, ZHANG Xin, HUANG Lisha, LIN Yansong
doaj   +1 more source

Program transformations using temporal logic side conditions [PDF]

, 2009
This paper describes an approach to program optimisation based on transformations, where temporal logic is used to specify side conditions, and strategies are created which expand the repertoire of transformations and provide a suitable level of ...
Aho A. V., Assmann U., Assmann U., Cleaveland R., David Lacey, Faith R. E., Heckmann R., Jones S. P., Kanade A., Klein M., Lacey D., Lipps P., Müller-Olm M., Paige R., Richard Warburton, Sara Kalvala, Sokolsky O., Steffen B., Steffen B., Vallée-Rai R., van Engelen R. A.   +20 more
core   +2 more sources