Results 41 to 50 of about 53,193 (289)

Physical-based optimization for non-physical image dehazing methods [PDF]

, 2020
Images captured under hazy conditions (e.g. fog, air pollution) usually present faded colors and loss of contrast. To improve their visibility, a process called image dehazing can be applied.
Bertalmío, Marcelo, Finlayson, Graham D., Vazquez-Corral, Javier   +2 more
core   +2 more sources

Case report: Recurrent lung infections following treatment with pralsetinib for an elderly patient with RET-fusion positive NSCLC

Frontiers in Oncology, 2022
Patients with RET fusions represent 1-2% of all cases of non-small cell lung cancer (NSCLC), the majority of whom are younger, and are extremely rare in the elderly.
Li An, Pengzhi Chen, Junfeng Wang, Xuebing Qin, Tingting Liu, Yanhong Gao, Peng Wang, Dong Zhang, Xiangqun Fang, Zhijian Zhang   +9 more
doaj   +1 more source

A RET::GRB2 fusion in pheochromocytoma defies the classic paradigm of RET oncogenic fusions

Cell Reports Medicine, 2022
The RET kinase receptor is a target of mutations in neural crest tumors, including pheochromocytomas, and of oncogenic fusions in epithelial cancers. We report a RET::GRB2 fusion in a pheochromocytoma in which RET, functioning as the upstream partner, retains its kinase domain but loses critical C-terminal motifs and is fused to GRB2, a physiological ...
Cynthia M. Estrada-Zuniga, Zi-Ming Cheng, Purushoth Ethiraj, Qianjin Guo, Hector Gonzalez-Cantú, Elaina Adderley, Hector Lopez, Bethany N. Landry, Abir Zainal, Neil Aronin, Yanli Ding, Xiaojing Wang, Ricardo C.T. Aguiar, Patricia L.M. Dahia   +13 more
openaire   +3 more sources

KIF5B-RET fusions in lung adenocarcinoma [PDF]

Nature Medicine, 2012
We identified in-frame fusion transcripts of KIF5B (the kinesin family 5B gene) and the RET oncogene, which are present in 1-2% of lung adenocarcinomas (LADCs) from people from Japan and the United States, using whole-transcriptome sequencing. The KIF5B-RET fusion leads to aberrant activation of RET kinase and is considered to be a new driver mutation ...
Takashi, Kohno, Hitoshi, Ichikawa, Yasushi, Totoki, Kazuki, Yasuda, Masaki, Hiramoto, Takao, Nammo, Hiromi, Sakamoto, Koji, Tsuta, Koh, Furuta, Yoko, Shimada, Reika, Iwakawa, Hideaki, Ogiwara, Takahiro, Oike, Masato, Enari, Aaron J, Schetter, Hirokazu, Okayama, Aage, Haugen, Vidar, Skaug, Suenori, Chiku, Itaru, Yamanaka, Yasuhito, Arai, Shun-Ichi, Watanabe, Ikuo, Sekine, Seishi, Ogawa, Curtis C, Harris, Hitoshi, Tsuda, Teruhiko, Yoshida, Jun, Yokota, Tatsuhiro, Shibata   +28 more
openaire   +2 more sources

Pralsetinib treatment for multiple fusions in lung adenocarcinoma: a case report

Journal of International Medical Research, 2022
Despite recent advances in treatments and knowledge of biomarkers, patients with metastatic lung cancer have a 5-year survival rate of 5%. Rearranged during transfection ( RET ) fusions occur in 1% to 2% of lung cancer patients. Pralsetinib has been used
Xiangming Cao, Xiongwei Liu, Simin Wang, Zhen Liu, Xin Ren, Debin Sun, Lichun Deng   +6 more
doaj   +1 more source

Architecture of coatomer: Molecular characterization of delta-COP and protein interactions within the complex [PDF]

, 1996
Copyright © 2011 by The Rockefeller University Press.Coatomer is a cytosolic protein complex that forms the coat of COP I-coated transport vesicles.
Auerbach, S, Faulstich, D, Harter, C, Lottspeich, F, Orci, L, Ravazzola, M, Stenbeck, G, Tschochner, H, Wegchingel, S, Wieland, FT   +9 more
core   +1 more source

Characteristics, treatment patterns, and biomarker testing of patients with advanced RET fusion-positive non-small cell lung cancer in a real-world multi-country observational study: a brief report

Frontiers in Oncology
IntroductionApproximately 1−2% of non-small cell lung cancers (NSCLCs) are positive for rearranged during transfection (RET) gene fusions. The aim of this real-world multi-national study was to describe clinical characteristics, biomarker testing, and ...
Urpo Kiiskinen, Grace Segall, Hollie Bailey, Cameron Forshaw, Tarun Puri   +4 more
doaj   +1 more source

Singly generated quasivarieties and residuated structures [PDF]

, 2019
A quasivariety K of algebras has the joint embedding property (JEP) iff it is generated by a single algebra A. It is structurally complete iff the free countably generated algebra in K can serve as A.
Anderson A. R., Bergman C., Chang C. C., Citkin A. I., Citkin A. I., Dywan Z., Esakia L. L., Esakia L. L., Galatos N., Gorbunov V. A., Jónsson B., Kuznetsov A. V., Magari R., Maltsev A. I., Maltsev A. I., Maltsev A. I., Minari P., Pogorzelski W. A., Pogorzelski W. A., Prucnal T., Rybakov V. V., Wroński A., Wroński A., Wroński A., Łoś J., Łoś J.   +25 more
core   +2 more sources

Drosophila Cancer Models Identify Functional Differences between Ret Fusions

Cell Reports, 2016
We generated and compared Drosophila models of RET fusions CCDC6-RET and NCOA4-RET. Both RET fusions directed cells to migrate, delaminate, and undergo EMT, and both resulted in lethality when broadly expressed.
Sarah Levinson, Ross L. Cagan
doaj   +1 more source

Real-world outcomes of chemoimmunotherapy and selective RET inhibitors in Chinese patients with RET fusion-positive non-small cell lung cancer

Heliyon
Background: Rearranged during transfection (RET) gene fusion is a target for non-small cell lung cancer (NSCLC) treatment, and RET inhibitors are approved for advanced NSCLC.
Rui Wan, Weihua Li, Zhijie Wang, Jia Zhong, Lin Lin, Jianchun Duan, Jie Wang   +6 more
doaj   +1 more source