Results 61 to 70 of about 53,193 (289)

FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells [PDF]

, 2014
Receptor Tyrosine Kinases (RTKs) and Focal Adhesion Kinase (FAK) regulate multiple signalling pathways, including mitogen-activated protein (MAP) kinase pathway. FAK interacts with several RTKs but little is known about how FAK regulates their downstream
A Bergmann, A Boulay, A Ueda, AC Dar, B Corkery, B Gabriel, BA Edgar, BA Hay, BJ Dickson, C Grabbe, CJ Marshall, D Tenenbaum, DD Schlaepfer, DJ Sieg, E Macia, E Rainero, E Rainero, E Sandilands, E Sandilands, Emma Sandilands, FD Karim, FJ Diaz-Benjumea, G Adam, GL Fox, I Bongarzone, I Plaza-Menacho, I Rebay, Iain MacPherson, IH Gelman, J Cordero, J Fujimoto, J Verdu, J Zhao, Jesica Diaz Vera, Jim C. Norman, JR Infante, JT Parsons, JT Price, Juan Pablo Macagno, K Blochlinger, K Halfar, K Mesaki, K Sawamoto, L Henriksen, L Sadowski, LV Owens, M Agochiya, M Ayaki, M Freeman, M Grieco, M Miaczynska, M Roberts, M Santoro, M Therrien, M Vidal, M Vidal, Marcos Vidal, Margaret Frame, Marshall S. Horwitz, MC Frame, ME Grether, ME Irwin, MM Bradford, P Kurada, P-I Tsai, PM Siesser, R Gleichauf, R Ohta, RD Read, RH Palmer, Ruth Palmer, S Leboulleux, S Murakami, S Rizzolio, S Sigismund, SA Speicher, SM Jhiang, SY Chen, T Das, T Matsuo, T-H Chen, W Long, WG Cance, X Zhao, Y Zheng, Yachuan Yu, Z Lu   +86 more
core   +4 more sources

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Combined RET and MEK Inhibition as a Treatment for RET Fusion-Positive NSCLC With Acquired BRAF Fusion: A Case Report

JTO Clinical and Research Reports
RET fusions are present in 1% to 2% of NSCLCs. Although RET inhibitors like selpercatinib are effective, resistance inevitably develops. We present the case of a 28-year-old female with recurrent NSCLC and a CCDC6::RET fusion treated with selpercatinib ...
Jacobi B. Hines, MD, Benjamin C. Bowar, PharmD, Margaret Colleton, MMS, Lydia Chelala, MD, Peng Wang, MD, Angad A. Chadha, MD, Jeremy Segal, MD, Christine M. Bestvina, MD   +7 more
doaj   +1 more source

The Hubble sequence: just a vestige of merger events? [PDF]

, 2009
Abr: We investigate whether the Hubble sequence can be reproduced by the relics of merger events. We verify that, at zmed=0.65, the abundant population of anomalous starbursts is mainly linked to the local spirals.
Alonso-Herrero, Barnes, Barnes, Barnes, Bell, Bell, Berentzen, Brinchmann, Brown, Bruzual, Carignan, Conselice, Conselice, Davidge, Davies, Dekel, Donner, E. Athanassoula, Eggen, Erb, F. Hammer, Fall, Flores, Gao, Gerin, Goldreich, Goldreich, Governato, H. Flores, Hammer, Hammer, Hammer, Hammer, Hammer, Heckman, Hopkins, Hopkins, Hopkins, Ibata, Jiang, Jogee, Kennicutt, Kroupa, Liang, Lilly, Lotz, Lotz, M. Puech, M. Rodrigues, Maller, Maller, Maraston, Marcillac, Mo, Mouhcine, Nakamura, Neff, Neichel, Noguchi, Peebles, Peirani, Poggianti, Puech, Puech, Puech, Puech, Puech, R. Delgado, Ravikumar, Rawat, Rawat, Robaina, Robertson, Rodrigues, Ryan, Schiminovich, Sheth, Silk, Springel, Springel, Steinmetz, Steinmetz, Stewart, Toomre, Toth, Tutukov, van den Bergh, Van den Bergh, White, Y. B. Yang, Yang, Yang, Zheng   +92 more
core   +3 more sources

Can Carbon Strategy Enhance Corporate Productivity? Evidence From Carbon Risk and Opportunity Management

Business Strategy and the Environment, EarlyView.
ABSTRACT Whether corporate carbon management can enhance productive efficiency is central to firms' long‐term competitiveness and determines whether carbon reduction efforts can be sustained beyond regulatory compliance. This study examines how corporate carbon risk and opportunity management affects firm productivity (measured by total factor ...
Nan Huang, Hanlu Fan, Ruoxin Zhu
wiley   +1 more source

Response to RET-Specific Therapy in RET Fusion-Positive Anaplastic Thyroid Carcinoma

Thyroid, 2020
Background: Anaplastic thyroid carcinoma (ATC) remains one of the most challenging malignancies to treat in the modern era. Most patients present with or develop recurrent/metastatic incurable disease with poor response rates to conventional chemotherapy, and life expectancy is short. Next-generation sequencing (NGS) can be leveraged in ATC to identify
Dias-Santagata, Dora, Lennerz, Jochen K., Sadow, Peter M., Frazier, Ryan P., Govinda Raju, Sandya, Henry, Dahlia, Chung, Trisha, Kherani, Jennifer, Rothenberg, S. Michael, Wirth, Lori J.   +9 more
openaire   +2 more sources

Dublin City University at CLEF 2004: experiments with the ImageCLEF St Andrew's collection [PDF]

, 2004
For the CLEF 2004 ImageCLEF St Andrew's Collection task the Dublin City University group carried out three sets of experiments: standard cross-language information retrieval (CLIR) runs using topic translation via machine translation (MT), combination ...
Groves, Declan, Jones, Gareth J.F., Khasin, Anna, Lam-Adesina, Adenike M., Mellebeek, Bart, Way, Andy   +5 more
core  

Quark and gluon distributions at the earliest stage of heavy ion collision [PDF]

, 1994
Using the general framework of quantum field kinetics we consider new principles to compute initial distribution of quarks and gluons after the first hard interaction of heavy ions. We start by rewriting the integral equations of QCD in the form which is
Makhlin, A.
core   +2 more sources

A Comparison of Regional Decisions for Doses and Administrations of New Drugs: Concordance, Discordance, and Dependencies

Clinical Pharmacology &Therapeutics, EarlyView.
Regional differences in approved drug dosages and administration are shaped by complex factors, including clinical data, prior regulatory decisions, and region‐specific considerations. This study investigated how such factors are associated with variations in approved doses across the United States Food and Drug Administration (FDA), European Medicines
Sachiko Mita, Shunsuke Ono
wiley   +1 more source

Efficacy and safety of selpercatinib in Chinese patients with advanced -altered thyroid cancers: results from the phase II LIBRETTO-321 study

Therapeutic Advances in Medical Oncology, 2022
Background: Selpercatinib, a highly selective and potent REarranged during Transfection (RET) kinase inhibitor, is effective in advanced RET -altered thyroid cancer (TC). However, the efficacy and safety in Chinese patients are unknown.
Xiangqian Zheng, Qinghai Ji, Yuping Sun, Minghua Ge, Bin Zhang, Ying Cheng, Shangtong Lei, Feng Shi, Ye Guo, Linfa Li, Lu Chen, Jingxin Shao, Wanli Zhang, Ming Gao   +13 more
doaj   +1 more source