Results 71 to 80 of about 53,193 (289)

Advanced EGFR-mutant NCSLC resistant to osimertinib therapy as a result of a novel CGN-RET fusion mutation with favorable response to combined osimertinib and selpercaptinib, case report

open access: yesCurrent Problems in Cancer: Case Reports, 2023
RET-fusions are a known cause of acquired osimertinib resistance in patients with advanced NSCLC. Herein we describe the case of a patient who developed resistance to osimertinib, via acquisition of a novel CGN-RET fusion mutation.
Hamid Mirshahidi   +4 more
doaj   +1 more source

Commodity Dynamics: A Sparse Multi-class Approach

open access: yes, 2016
The correct understanding of commodity price dynamics can bring relevant improvements in terms of policy formulation both for developing and developed countries.
Barbaglia, Luca   +2 more
core   +1 more source

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

open access: yesDrug Testing and Analysis, EarlyView.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

Preclinical Modeling of KIF5B–RET Fusion Lung Adenocarcinoma [PDF]

open access: yesMolecular Cancer Therapeutics, 2016
Abstract RET fusions have been found in lung adenocarcinoma, of which KIF5B–RET is the most prevalent. We established inducible KIF5B-RET transgenic mice and KIF5B–RET-dependent cell lines for preclinical modeling of KIF5B–RET-associated lung adenocarcinoma.
Qingling, Huang   +13 more
openaire   +2 more sources

Brain Metastases From Differentiated Thyroid Cancer in the Era of Targeted Therapies: A Multi‐Center Retrospective Cohort

open access: yesHead &Neck, EarlyView.
ABSTRACT Background Brain metastases (BM) of differentiated thyroid carcinoma (DTC) are associated with unfavorable prognosis. This study evaluated BM management strategies and patients' outcomes. Methods A retrospective review of patients diagnosed with DTC and BM at Tel Aviv Sourasky and Rabin Medical Centers between 1985 and 2024. Clinical features,
Liyona Kampel   +9 more
wiley   +1 more source

Chinese pan‐cancer patient genomic characteristics: A comprehensive analysis based on the National Cancer Center–Clinical Diagnostics Knowledgebase real‐world clinical sequencing cohort

open access: yesInterdisciplinary Medicine, EarlyView.
We assembled National Cancer Center–Clinical Diagnostics Knowledgebase, a clinical genomic knowledgebase of 6935 tumors with matched normal samples, revealing key somatic alterations and actionable variants (70.2% of the cohort). Enrichment of certain different gene mutations was observed between Chinese and American populations, along with a strong ...
Hongrui Li   +10 more
wiley   +1 more source

On the study of catalytic membrane reactor for water detritiation: Membrane characterization. [PDF]

open access: yes, 2013
Tritium waste recycling is a real economic and ecological issue. Generally under the non-valuable Q2Oform (Q = H, D or T), waste can be converted into fuel Q2for a fusion machine (e.g. JET, ITER) by isotopeexchange reaction Q2O + H2= H2O + Q2.
Joulia, Xavier   +6 more
core   +2 more sources

Employee Satisfaction and Real Activities Earnings Management

open access: yesJournal of Corporate Accounting &Finance, EarlyView.
ABSTRACT This paper examines the relation between employee satisfaction and real activities earnings management. Based on a holistic view of the balanced scorecard approach, employee satisfaction often plays a role in promoting desirable corporate outcomes.
Jaeseong Lim
wiley   +1 more source

Research Progress of Fusion Genes RET in Non-small Cell Lung Cancer

open access: yesChinese Journal of Lung Cancer, 2021
In the past 20 years, with the development of molecular biology, the treatment of non-small cell lung cancer (NSCLC) has been developing. Targeted therapy has improved the survival period of patients with positive mutation of tumor driver gene.
Yujun ZHENG   +6 more
doaj   +1 more source

INTEGRATIVE ANALYSIS OF OMICS DATA IN ADULT GLIOMA AND OTHER TCGA CANCERS TO GUIDE PRECISION MEDICINE [PDF]

open access: yes, 2017
Transcriptomic profiling and gene expression signatures have been widely applied as effective approaches for enhancing the molecular classification, diagnosis, prognosis or prediction of therapeutic response towards personalized therapy for cancer ...
hu, Xin, hu, xin
core   +1 more source

Home - About - Disclaimer - Privacy