Results 131 to 140 of about 837,121 (281)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Seismic Earth Pressure Development in Sheet Pile Retaining Walls: A Numerical Study

, 2014
The design of retaining walls requires the complete knowledge of the earth pressure distribution behind the wall. Due to the complex soil-structure effect, the estimation of earth pressure is not an easy task; even in the static case. The problem becomes
Bui, Ha H., Rajeev, P., Sivakugan, N.
core   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Study on Deformation Characteristics of Deep Foundation Pit Soil and Retaining Structure of Subway Station in Guangzhou Area With Composite Strata

Advances in Civil Engineering
The excavation of the deep foundation pit of subway station may cause excessive deformation of foundation pit and retaining structure and then pose a threat to the safety of surrounding buildings and people.
Wufeng Mao, Wentian Xu, Yanmei Ruan, Xinyu Tian   +3 more
doaj   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Dynamic soil-structure interaction between retaining walls, retaining soil and retained structures

Summarization: Dynamic soil response and dynamic soil-structure interaction (DSSI) play an important role on the seismic response and distress of all engineering structures. The role of soil response and DSSI can be either beneficial or detrimental depending on the relationship between the dynamic characteristics of: (a) the seismic excitation(s) at ...
Psarropoulos Prodromos N.(), Τσομπανακης Ιωαννης(http://users.isc.tuc.gr/~itsobanakis), Tsompanakis Ioannis(http://users.isc.tuc.gr/~itsobanakis), Κατσιρακης Εμμανουηλ(http://users.isc.tuc.gr/~ekatsirakis), Katsirakis Emmanouil(http://users.isc.tuc.gr/~ekatsirakis)   +4 more
openaire   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Exact methods for modal transient response analysis including feedback control [PDF]

This paper presents a modal method for the analysis of controlled structural systems that retains the uncoupled nature of the classical transient response analysis of a structure subjected to a prescribed time-varying load.
Anderson, Melvin S., Belvin, W. Keith
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source