Results 51 to 60 of about 837,121 (281)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Mechanical performance of composite retaining and protection structure for super large and deep foundation excavations

open access: yesJournal of Civil Engineering and Management, 2019
The reliable retaining methods and a good stress system are the key to the success of super large and deep excavation engineering. In this paper, the deepest foundation pit in Hainan province is taken as an example.
Zhen Cui, Qimin Li, Jian Wang
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Necessity of Inverted Supports in the Inclined Strut Section of the Foundation Pit with Strip Bottom Plate and Diaphragm Wall

open access: yesChengshi guidao jiaotong yanjiu
[Objective] In order to save project investment, strip bottom plates that are not fully closed are used for the foundation pit bottom sealing in some foundation pit inclined strut sections. After the removal of the lowest supports in such foundation pits,
YANG Kaiwu   +4 more
doaj   +1 more source

Generalizing Boolean Satisfiability I: Background and Survey of Existing Work

open access: yes, 2011
This is the first of three planned papers describing ZAP, a satisfiability engine that substantially generalizes existing tools while retaining the performance characteristics of modern high-performance solvers.
Dixon, H. E.   +2 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Three-Dimensional Reconstruction of Retaining Structure Defects from Crosshole Ground Penetrating Radar Data Using a Generative Adversarial Network

open access: yesRemote Sensing
Crosshole ground penetrating radar (GPR) is an efficient method for ensuring the quality of retaining structures without the need for excavation. However, interpreting crosshole GPR data is time-consuming and prone to inaccuracies.
Donghao Zhang   +4 more
doaj   +1 more source

Pile groups subjected to abrupt collapse of retaining structure

open access: yesGrađevinar, 2018
Excavations supported by retaining structures are very common in the construction of new structures in urban and hilly areas. This paper presents behaviour of model piles of various configurations, when exposed to soil movement induced by collapse of the
Rajesh Prasad Shukla
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Research on active earth pressure of narrow cohesionless backfill against rigid walls considering the arching effect

open access: yesFrontiers in Physics
Retaining walls are usually located next to existing structures. This runs counter to the traditional theoretical presumption of semi-infinite space, making it unsuitable to continue applying Coulomb’s theory.
Yanchen Liu, Renrong Li, Yu Wang
doaj   +1 more source

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