Results 141 to 150 of about 3,521,542 (389)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Recruitment and retention [PDF]
British Dental Journal, 2020 I, Hussain, A, Thomson, T, Norfolk
openaire +2 more sources
“Membership Retention in the Fitness Industry: A Qualitative Study and the Development of a Predictive Model" [PDF]
, 2008 The concern over poor membership retention rates in the fitness industry is increasing, yet it has attracted little empirical research. So far, membership retention has mostly been indirectly and narrowly addressed, whereby research has either measured ...
Francis-Smythe, Jan, Watts, Helen
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Understanding Polyamidoamine Epichlorohydrin (PAAE) Retention in Paper
BioResourcesPolyamidoamine epichlorohydrin (PAAE) is a permanent wet strength resin used in papermaking. When applied to paperboard, some amount of resin is retained in the sheet, and some is lost to the white water.
Yao Ntifafa, Yun Ji, Peter W. Hart
doaj
The Retention Phase of Treatment Retention - Still the Stepchild
Australasian Orthodontic Journal, 1993 Abstract This is the second in a series of three articles on The Retention Phase of Treatment taken from presentations given at the 1992 Annual Clinical Day meeting of the Victorian Branch of the A.S.O.
openaire +3 more sources
The MX-Helix of Muscle nAChR Subunits Regulates Receptor Assembly and Surface Trafficking. [PDF]
, 2020 Nicotinic acetylcholine receptors (AChRs) are pentameric channels that mediate fast transmission at the neuromuscular junction (NMJ) and defects in receptor expression underlie neuromuscular disorders such as myasthenia gravis and congenital myasthenic ...
Borges, Lucia Soares +3 more
core