Results 191 to 200 of about 2,837,491 (342)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Evaluating phone call follow-ups in Sub-Saharan Africa: A systematic review and meta-analysis. [PDF]

PLoS One
Musa AZ, Akinsolu FT, Salako AO, Abodunrin OR, Ola OM, Ezechi OC.   +5 more
europepmc   +1 more source

RETENTION OF URINE [PDF]

BMJ, 1930
openaire   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The race to retain nursing workforce in healthcare: an umbrella review of effectiveness of retention interventions and strategies. [PDF]

BMC Health Serv Res
Kiptulon EK, Elmadani M, Szőllősi A, Zrínyi M, Siket AU.   +4 more
europepmc   +1 more source

Retention of Urine [PDF]

BMJ, 1949
openaire   +3 more sources

A STUDY OF THE RETENTION OF URIC ACID DURING FASTING

, 1925
William G. Lennox, M.R. O’Connor
openalex   +1 more source

INSTRUMENT FOR THE RELIEF OF RETENTION OF URINE. [PDF]

, 1890
Amy Davis
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Longitudinal Impact of Grade Retention on Student Engagement with School: Challenges to Inclusive Education and to Person-Centered Schools. [PDF]

Eur J Investig Health Psychol Educ
Sousa A, Rodrigues MJ, Rodrigues M, Poltz N, Conde-Rodriguez A, Moreira PAS.   +5 more
europepmc   +1 more source