Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Prediction of Thermal Modulated Comprehensive Two-Dimensional Gas Chromatographic Separation Using a Modular, Graph-Based Simulation Platform. [PDF]
Leppert J, Brehmer T, Wüst M.
europepmc +1 more source
An Actionable Framework for Understanding and Improving Talent Retention as a Competitive Advantage in IT Organizations [PDF]
Luiz Alexandre Costa +6 more
openalex +1 more source
Conceptual classification model for Sustainable Flood Retention Basins [PDF]
Miklas Scholz, Adam J. Sadowski
openalex +1 more source
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Assessing Retention in Care and Factors Associated With Antiretroviral Therapy Among People Living With HIV in the Upper West Region of Ghana: A Retrospective Cohort Study. [PDF]
Ping-Naah H +7 more
europepmc +1 more source
An investigation into the key components of internal employer brand and its’ impact on organisational performance and retention of talent within the recruitment sector in Ireland [PDF]
Aisling C. Murray
openalex
Multi-Night Sleep Restriction Impairs Long-Term Retention of Factual Knowledge in Adolescents [PDF]
James N. Cousins +2 more
openalex +1 more source
Microfluidic electro‐viscoelastic manipulation of extracellular vesicles
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh +7 more
wiley +1 more source
Development of an automated ultrasonographic detection method for fecal retention using a transgluteal cleft approach. [PDF]
Matsumoto M +7 more
europepmc +1 more source

