Results 91 to 100 of about 413,485 (267)

Retention-in-care and associated factors among adolescents living with sickle-cell disease in Kampala Uganda

Journal of Interventional Epidemiology and Public Health
Introduction: Worldwide sickle-cell disease has been identified as the most widespread genetic disorder highest in low-income countries. In Uganda, approximately 25,000 babies are born with sickle cell disease every year.
Patience Birungi, Francis Xavier Kasujja, Aggrey Mukose, Philip Kasirye, Angela Nakanwagi Kisakye, Juliet Kiguli   +5 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

A retrospective cohort analysis of people living with HIV/AIDS enrolled in HIV care at a reference center in Antananarivo, Madagascar

Frontiers in Public Health
BackgroundThe impact of the “Treat all” policy on the individual and in terms of public health is closely related to early diagnosis and retention in care. Patient-level data are scarce in Madagascar.
Mihaja Raberahona, Mihaja Raberahona, Rado Rakotomalala, Volatiana Andriananja, Johary Andriamamonjisoa, Etienne Rakotomijoro, Radonirina Lazasoa Andrianasolo, Rivonirina Andry Rakotoarivelo, Mamy Jean de Dieu Randria, Mamy Jean de Dieu Randria   +9 more
doaj   +1 more source

Retention in Continuous Care and Sustained Viral Suppression.

Journal of the International Association of Providers of AIDS Care, 2017
To examine the relationship between retention in continuous care and sustained viral suppression.The authors retrospectively followed 653 persons who were virally suppressed and seeking care at an infectious disease clinic in Kentucky for an average of 6 years to determine the rates of retention in medical care (≥2 visits separated by ≥3 months within ...
Timothy N. Crawford PhD, MPH, Alice Thornton MD   +1 more
openaire   +2 more sources

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

HIV Care Retention and Cost Analysis in Multi‐Month ART Dispensing: A Randomized Controlled Trial in China

Journal of the International AIDS Society
Introduction Multi‐month dispensing (MMD), as a differentiated service delivery model, can reduce the frequency of clinic visits, waiting time and travel costs for clinically stable people living with HIV.
Wenqi Shang, Yanyan Zhu, Ying He, Xiaolin Li, Qinghai Hu, Hong Sun, Wenqing Geng, Hong Shang, Haibo Ding   +8 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Essential Newborn Care Virtual Simulations for Skills Retention in Newborn Care

JAMA Network Open
ImportanceNewborn mortality accounts for approximately 47% of all mortality of children under the age of 5 years. Virtual simulation may be a viable approach to support retention of essential newborn care knowledge and skills among health care professionals in low- and middle-income countries.ObjectiveTo evaluate the association between mobile virtual ...
Umoren, Rachel A., Ezeaka, Chinyere, Berkelhamer, Sara K., Hippe, Daniel S., Asangansi, Ime E., Cook, Matthew W., Fajolu, Iretiola B., Olawuyi, Olubukola, Adeboboye, Christianah, Ekhalufoh, Oluwadamilola O., Fashola, Omolola S., Feltner, John, Fisher, Joseph D., James, Jasmine M., Imoukhuede, Olukemi M., Park, Nahee, Quach, Victoria, Stiffler, Amanda K., Engmann, Cyril M.   +18 more
openaire   +2 more sources