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Modeling of retinal degeneration

Bulletin of Experimental Biology and Medicine, 2021
We developed a model of retinal degeneration in rabbits based on exposure to light with a wavelength of 405 nm. This model allows reproducing structural and functional disorders in the central parts of the retina, including primarily degeneration of the outer layers of the retina (retinal pigment epithelium and layer of photoreceptor cells), and is ...
A A, Suetov   +4 more
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Retinal remodeling during retinal degeneration

Experimental Eye Research, 2005
Retinal degenerations, regardless of the initiating event or gene defect, often result in a loss of photoreceptors. This formal deafferentation of the neural retina eliminates the intrinsic glutamatergic drive of the sensory retina and, perhaps more importantly, removes coordinated Ca++-coupled signaling to the neural retina.
Bryan W, Jones, Robert E, Marc
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Retinal Degeneration in Kittens

Journal of the American Veterinary Medical Association, 1973
SUMMARY Diffuse outer segment retinal degeneration was found in 2 Persian kittens in each of 2 successive litters by 15 weeks of age. Clinical signs were mydriasis, tapetal hyperreflectivity, retinal vascular attenuation, and abnormalities in visual behavior. The disease seemed to be inherited as a simple autosomal recessive trait.
L F, Rubin, D E, Lipton
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Peripapillary Pigmentary Retinal Degeneration

American Journal of Ophthalmology, 1978
We studied four patients with peripapillary pigmentary retinal degeneration, an asymptomatic disorder that was probably benign and nonprogressive. The ophthalmoscopic appearance showed a segmental, grayish metallic sheen in association with bone spicule pigmentation, which radiated from the disk along the temporal vessel arcades and joined temporal to ...
K G, Noble, R E, Carr
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RETINAL DEGENERATION IN GREYHOUNDS

Australian Veterinary Journal, 1980
Retinal degeneration in 10 Greyhounds with clinical and ophthalmoscopic features is described, including results of electroretinography and fluorescein angiography for one affected dog. Clinical and histologic features differed from other kinds of retinal degeneration in dogs.
D H, Slatter, J R, Blogg, I J, Constable
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Feline Central Retinal Degeneration

Journal of the American Veterinary Medical Association, 1970
SUMMARY Feline central retinal degeneration (fcrd) was found in 25 domestic cats. It was characterized by a focus of retinal degeneration in the macular region involving the outer retinal layers. The cause of this condition was undetermined.
R W, Bellhorn, C A, Fischer
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Late-Onset Retinal Degeneration

2018
Patients with late-onset retinal degeneration (LORD) usually present with nyctalopia in the fifth or sixth decade of life. The fundus shows yellowish-white, punctate deposits, usually progressive and giving rise to scalloped areas of retinal pigment epithelium (RPE) atrophy in the mid-periphery and posterior pole (Fig. 23.1). The anterior segment shows
Stephen H, Tsang, Tarun, Sharma
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