Results 301 to 310 of about 640,739 (357)

Longitudinal Visual Biomarkers in Dominant Optic Atrophy: A Systematic Review and Meta‐Analysis

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Dominant Optic Atrophy (DOA) causes slowly progressive visual decline usually beginning in childhood. As new therapies come to clinical trial, the choice of biomarkers to be used as clinical trial endpoints has become a critical question to be addressed. Methods We undertook a systematic review and meta‐analysis of studies reporting
Christopher A. Ovens, John R. Grigg, Clare L. Fraser   +2 more
wiley   +1 more source

Quercetin Alleviates All-Trans-Retinal-Induced Photoreceptor Apoptosis and Retinal Degeneration by Inhibiting the ER Stress-Related PERK Signaling. [PDF]

Int J Mol Sci
Yang B, Yang K, Xi R, Chen J, Wu Y.
europepmc   +1 more source

Efficient Rescue of Retinal Degeneration in Pde6a Mice by Engineered Base Editing and Prime Editing. [PDF]

Adv Sci (Weinh)
Liu Z, Chen S, Davis AE, Lo CH, Wang Q, Li T, Ning K, Zhang Q, Zhao J, Wang S, Sun Y.   +10 more
europepmc   +1 more source

Retinal Degeneration Associated With Biallelic RDH12 Variants: Longitudinal Evaluation of Retinal Structure and Visual Function in Pediatric Patients. [PDF]

Invest Ophthalmol Vis Sci
Aleman TS, Roman AJ, Uyhazi KE, Jiang YY, Bedoukian EC, Sumaroka A, Wu V, Swider M, Viarbitskaya I, Russell RC, Shagena EO, Santos AJ, Serrano LW, Parchinski KM, Kim RJ, Weber ML, Garafalo AV, Thompson DA, Maguire AM, Bennett J, Scoles DH, O'Neil EC, Morgan JIW, Cideciyan AV.   +23 more
europepmc   +1 more source

Hyperreflective retinal foci are associated with retinal degeneration after optic neuritis in neuromyelitis optica spectrum disorders and multiple sclerosis. [PDF]

Eur J Neurol
Klyscz P, Vigiser I, Solorza Buenrostro G, Motamedi S, Leutloff CJ, Schindler P, Schmitz-Hübsch T, Paul F, Zimmermann HG, Oertel FC.   +9 more
europepmc   +1 more source

The RNA content of extracellular vesicles from gene-edited <i>PRPF31</i> ^+/- hiPSC-RPE show potential as biomarkers of retinal degeneration. [PDF]

Mol Ther Methods Clin Dev
Getachew H, Mehrotra S, Kaur T, Fernandez-Godino R, Pierce EA, Garita-Hernandez M.   +5 more
europepmc   +1 more source

Rabin8 phosphorylated by NDR2, the canine early retinal degeneration gene product, directs rhodopsin Golgi-to-cilia trafficking.

J Cell Sci
Fresquez T, Tam BM, Eshelman SC, Moritz OL, Robichaux MA, Deretic D.   +5 more
europepmc   +1 more source

Microglia Polarization with M1/M2 Phenotype Changes in rd1 Mouse Model of Retinal Degeneration

Frontiers in Neuroanatomy, 2017
Microglia activation is recognized as the hallmark of neuroinflammation. However, the activation profile and phenotype changes of microglia during the process of retinal degeneration are poorly understood.
Tian Zhou, Chang He
exaly   +2 more sources