Results 61 to 70 of about 640,739 (357)

Maturation and Protection Effect of Retinal Tissue-Derived Bioink for 3D Cell Printing Technology

Pharmaceutics, 2021
Retinal degeneration is a leading cause of incurable vision loss and blindness. The increasing incidence of retinal degeneration has triggered research into the development of in vitro retinal models for drug development and retinal alternatives for ...
Jongmin Kim, Jeong Sik Kong, Hyeonji Kim, Wonil Han, Jae Yon Won, Dong-Woo Cho   +5 more
doaj   +1 more source

Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration

Molecular Neurodegeneration, 2018
The role of the alternative complement pathway and its mediation by retinal microglia and macrophages, is well-established in the pathogenesis of Age-Related Macular Degeneration (AMD).
Haihan Jiao, Matt Rutar, Nilisha Fernando, T. Yednock, S. Sankaranarayanan, Riemke Aggio‐Bruce, J. Provis, R. Natoli   +7 more
semanticscholar   +1 more source

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

Induced pluripotent stem cells and derivative photoreceptor precursors as therapeutic cells for retinal degenerations

Tzu Chi Medical Journal, 2020
The visual impairment associated with inherited retinal degeneration and age-related degeneration of photoreceptors is causing substantial challenges in finding effective therapies.
Rupendra Shrestha, Yao-Tseng Wen, Rong-Kung Tsai   +2 more
doaj   +1 more source

Course of Sodium Iodate-Induced Retinal Degeneration in Albino and Pigmented Mice.

Investigative Ophthalmology and Visual Science, 2017
Purpose To characterize the course of sodium iodate (SI)-induced retinal degeneration in young adult albino and pigmented mice. Methods Single intraperitoneal (IP) injections of SI (25, 50, and 100 mg/kg) were performed in 7- to 8-week-old BALB/c and ...
Guy Chowers, Matan J. Cohen, Devorah Marks-Ohana, Shelly Stika, Ayala Eijzenberg, E. Banin, A. Obolensky   +6 more
semanticscholar   +1 more source

General Pathophysiology in Retinal Degeneration [PDF]

, 2014
Retinal degeneration, including that seen in age-related macular degeneration and retinitis pigmentosa (RP), is the most common form of neural degenerative disease in the world. There is great genetic and allelic heterogeneity of the various retinal dystrophies.
Stephen H. Tsang, Stephen H. Tsang, Stephen H. Tsang, Katherine J. Wert, Jonathan H. Lin   +4 more
openaire   +3 more sources

Immune Checkpoint PD‐L1 Modulates Retinal Microglial Activation to Alleviate Vascular Leakage in Choroidal Neovascularization via ERK

Advanced Science, EarlyView.
PD‐L1 limits neuroinflammation in neovascular AMD by modulating microglial activation. Its deficiency exacerbates vascular leakage and choroidal neovascularization (CNV) via ERK signaling, while enhancing PD‐L1 reduces inflammation and neovascularization. Targeting PD‐L1 may offer a novel immunomodulatory strategy for NVAMD.
Yue Zou, Junliang Jiang, Yunqin Li, Xinyi Ding, Qiuping Tong, Ying Shi, Lei Xiao, Ling Chen   +7 more
wiley   +1 more source

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

Protection of retina by αB crystallin in sodium iodate induced retinal degeneration. [PDF]

PLoS ONE, 2014
Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. The retinal pigment epithelium (RPE) is a critical site of pathology in AMD and αB crystallin expression is increased in RPE and associated drusen in AMD.
Peng Zhou, Ram Kannan, Christine Spee, Parameswaran G Sreekumar, Guorui Dou, David R Hinton   +5 more
doaj   +1 more source

Electrophysiological properties of layer 2/3 pyramidal neurons in the primary visual cortex of a retinitis pigmentosa mouse model (rd10)

Frontiers in Cellular Neuroscience, 2023
Retinal degeneration is one of the main causes of visual impairment and blindness. One group of retinal degenerative diseases, leading to the loss of photoreceptors, is collectively termed retinitis pigmentosa.
Claas Halfmann, Thomas Rüland, Thomas Rüland, Thomas Rüland, Frank Müller, Frank Müller, Frank Müller, Kevin Jehasse, Björn M. Kampa, Björn M. Kampa, Björn M. Kampa, Björn M. Kampa   +11 more
doaj   +1 more source