Results 311 to 320 of about 511,957 (402)

Heterogeneous metabolic response of endothelial cells from different vascular beds to experimental hyperglycaemia and metformin

The Journal of Physiology, EarlyView.
Abstract figure legend Diabetes mellitus is associated with vascular pathology that leads to vascular complications in several tissues, such as retinopathy of the eye. Endothelial dysfunction plays a pivotal role in the progression of each complication.
C. McAleese, G. Joudah, I. P. Salt, J. R. Petrie, J. M. Leiper, Laura B. Dowsett   +5 more
wiley   +1 more source

Early photoreceptor assessment as a predictor for visual acuity gain after vitrectomy for macula-off retinal detachment. [PDF]

Int J Retina Vitreous
Vidal-Oliver L, Mataix-Boronat J, Mangen M, Alfonso-Muñoz E, Palacios-Pozo E, López-Prats MJ, Desco C.   +6 more
europepmc   +1 more source

Impaired angiogenesis in gestational diabetes is linked to succinate/SUCNR1 axis dysregulation in late gestation

The Journal of Physiology, EarlyView.
Abstract figure legend Gestational Diabetes Mellitus (GDM) impacts on succinate metabolism and angiogenesis in the umbilical cord endothelium. (Left Panel) Succinate levels increase in both maternal and fetal circulation at delivery, with higher concentrations observed in GDM pregnancies compared to controls during late gestation.
Sergiy Klid, Francisco Algaba‐Chueca, Elsa Maymó‐Masip, Mónica Ballesteros, Montse Inglés, Albert Guarque, Nerea Vilanova‐Ricart, Ariadna Prats, Azra Kulovic‐Sissawo, Elisa Weiss, Ursula Hiden, Joan Vendrell, Sonia Fernández‐Veledo, Ana Megía   +13 more
wiley   +1 more source

Exudative retinal detachment and hypertensive choroidopathy in a patient with suspected HELLP syndrome: a case report. [PDF]

BMC Ophthalmol
Li M, Qu J.
europepmc   +1 more source

Case Report: Association of Ocular Colobomas With a Novel Missense Variant in CDC42, a Member of the Rho Family of Small GTPases

Clinical Genetics, Volume 108, Issue 5, Page 589-593, November 2025.
We report a 2‐year‐old male with clinical features of Takenouchi‐Kosaki syndrome, bilateral colobomas, and a de novo, likely pathogenic missense variant in CDC42. Supportive evidence includes a Cdc42 conditional knock‐out mouse model with colobomas.
Diana Brightman, Nawaal Shinwari, Aleksey Porollo, Eniolami O. Dosunmu, Ehsan Ullah, Bin Guan, Robert B. Hufnagel, Brian P. Brooks, Delphine Blain, Sabine Fuhrmann, Brittany Simpson, Anne M. Slavotinek   +11 more
wiley   +1 more source

The TP53 Arg72Pro polymorphism predicts visual and neurodegenerative outcomes in retinal detachment. [PDF]

Cell Death Dis
Galindo-Cabello N, Sobas-Abad EM, Lapresa R, Agulla J, Almeida Á, López A, Pastor JC, Pastor-Idoate S, Usategui-Martín R.   +8 more
europepmc   +1 more source

Treatment With Remdesivir Alone or in Combination With GS‐441524 in Cats With Ocular Involvement of Feline Infectious Peritonitis: An Observational Case Series

Journal of Veterinary Internal Medicine, Volume 39, Issue 6, November/December 2025.
ABSTRACT Background Remdesivir and GS‐441524 have successfully treated cats with feline infectious peritonitis (FIP) but the changes in associated signs of ocular disease are not reported. Objective Evaluate the response of FIP‐associated signs of ocular disease before and after treatment with remdesivir, GS‐441524, or both.
Amy L. M. M. Andrews, Eneko Izaguirre, Jodie Green, Emma Scurrell, Savina Gogova, Sarah Tayler, Christiane Kafarnik   +6 more
wiley   +1 more source

Timing of Epiretinal Membrane Surgery After Uncomplicated Retinal Detachment Repair. [PDF]

J Vitreoretin Dis
Bomdica PR, Shepherd EA, Gupta R, Chaturvedi V.   +3 more
europepmc   +1 more source

Pigment Epithelium‐Derived Factor (PEDF)‐Based Therapy Induced Photoreceptor Survival by Stabilizing Choroidal Neovessels in a VEGF Overexpression CNV Rat Model

The FASEB Journal, Volume 39, Issue 19, 15 October 2025.
Stabilizing choroidal neovessels offers a novel treatment‐option for pathological CNV. Pigment epithelium‐derived factor (PEDF), a multifunctional protein with vessel‐stabilizing properties, is a promising candidate for this approach. Its efficacy with and without bevacizumab was tested in a VEGF overexpression CNV rat model.
Alexander V. Tschulakow, Lei Xi, Ulrich Schraermeyer, Sylvie Julien   +3 more
wiley   +1 more source