Results 61 to 70 of about 341,800 (306)

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

Advanced Science, EarlyView.
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li   +12 more
wiley   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Unilateral serous retinal detachment with choroidal thickening as a first presenting sign of acute myeloid leukemia

American Journal of Ophthalmology Case Reports, 2019
Purpose: Serous retinal detachment is rare in leukemia, but bilateral or unilateral cases have been reported as the presenting sign of acute leukemia or the first sign of relapsing leukemia.
Tatsuma Kishimoto, Ken Fukuda, Takashi Nishiuchi, Nobutsugu Hayashi, Atsuki Fukushima   +4 more
doaj   +1 more source

Incidence and Risk Factors of Iatrogenic Retinal Breaks: 20-Gauge versus 25-Gauge Vitrectomy for Idiopathic Macular Hole Repair

Journal of Ophthalmology, 2020
Purpose. We compared the incidences of iatrogenic retinal breaks and postoperative retinal detachment between eyes that underwent 20-gauge vitrectomy and those that underwent 25-gauge vitrectomy for idiopathic macular hole repair. Methods.
Norio Fujiwara, Goji Tomita, Fumihiko Yagi   +2 more
doaj   +1 more source

Preventing Retinal Detachment: Where are We? Implications from Stickler Syndrome

, 2022
Robert E Morris,1– 3 Ferenc Kuhn,2,4 Timothy Sipos1– 3 1Retina Specialists of Alabama, LLC, Birmingham, AL, USA; 2Helen Keller Foundation for Research and Education, Birmingham, AL, USA; 3Department of Ophthalmology, University of Alabama at ...
Sipos T, Morris RE, Kuhn F
core  

Engineering Intelligent iPSC Biomanufacturing: Integrating Robotic Automation, AI, and Process Control

Advanced Intelligent Systems, EarlyView.
This review highlights recent advances in automated iPSC culture systems integrating robotics, advanced imaging, artificial intelligence, and process control. These technologies improve reproducibility, scalability, and quality in cell expansion, differentiation, and real‐time monitoring, while emerging AI‐enabled and closed‐loop approaches offer new ...
Hyoryong Lee, Roma Desai, Byunggik Kim, Deok‐Ho Kim   +3 more
wiley   +1 more source

Transient tractional retinal detachment in an eye with retinitis pigmentosa

Clinical Ophthalmology, 2010
Shuichiro Hirahara, Yoshio Hirano, Tsutomu Yasukawa, Yuichiro OguraDepartment of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanAbstract: We present a case of retinitis pigmentosa with ...
Shuichiro Hirahara, Yoshio Hirano, Tsutomu Yasukawa, et al   +3 more
doaj  

Posterior pole retinal detachment due to a macular hole in a patient with a Boston Keratoprosthesis

American Journal of Ophthalmology Case Reports, 2017
Purpose: To describe the clinical course of a patient with a Boston Keratoprosthesis type I who developed a localized posterior pole retinal detachment secondary to a macular hole.
Daniel Gologorsky, Basil K. Williams, Jr., Harry W. Flynn, Jr.   +2 more
doaj   +1 more source

RETINAL DISPLACEMENT AFTER RETINECTOMY IN COMPLEX MACULA-INVOLVING RECURRENT RHEGMATOGENOUS RETINAL DETACHMENT

Retinectomy, essential for treating complex rhegmatogenous retinal detachment, significantly risks retinal displacement, detectable through fundus autofluorescence.
Shaheen, Abdulla, Ghalibafan, Seyyedehfatemeh, Grau, Maria Magraner, Yannuzzi, Nicolas A., Sridhar, Jayanth, Leal, Sebastian, Rohowetz, Landon J., Cai, Louis Z.   +7 more
core   +1 more source

Progressive Visual Loss Without Retinal Detachment in Stickler Syndrome: An Uncommon and Novel Presentation

, 2020
Stickler syndrome is known to cause visual handicap due to the high incidence of retinal detachment. We aim to present an unusual case of a child with Stickler syndrome who had progressive visual loss secondary to atrophy of the outer retinal layers not ...
Ana Navarrete, Vardiella Meiner, Radgonde Amer, Jaime Levy, Adva Kimchi, Claudia Yahalom   +5 more
core   +1 more source