Results 201 to 210 of about 2,588,152 (306)

Systemic Diseases and the Eye: A Translational Perspective on Diabetes

Chronic Diseases and Translational Medicine, EarlyView.
The eye–brain–cardiometabolic axis in diabetes: retinal biomarkers as indicators of systemic disease. ABSTRACT Diabetes mellitus is a global chronic disease that affects the whole body and not just glucose metabolism. In diabetes, non‐invasive ocular changes can help understand microvascular, neurodegenerative, and inflammatory processes. This analysis
Matteo Capobianco, Marco Zeppieri, Simonetta Gaia Nicolosi, Niccolò Castellino, Francesco Cappellani, Irene Gattazzo, Caterina Gagliano   +6 more
wiley   +1 more source

KIF1A‐Mediated Axonal Transport of Netrin‐1 in iPSC‐Derived Human Forebrain Neurons

Cytoskeleton, EarlyView.
ABSTRACT Netrin‐1 is a secreted laminin‐like protein that functions as a guidance cue for axon pathfinding in development. Netrin‐1 also modulates synapse formation in developing neurons and long‐term potentiation in mature neurons. Netrin‐1 is expressed in human neurons; however, its intracellular distribution and trafficking have not been assessed ...
T. Y. Leung, J. Sidhu, A. Hsieh, Y. Ma, J. Liu, M. A. Silverman   +5 more
wiley   +1 more source

The Genetic Landscape of Inherited Retinal Diseases in the Israeli Population. [PDF]

Invest Ophthalmol Vis Sci
Shalom S, Gradstein L, Pras E, Valensi J, Birk OS, Blumenfeld A, Eilat A, Macarov M, Poleg T, Cremers FPM, Roosing S, Panneman DM, Hollander N, Goldenberg-Cohen N, Yahalom C, Banin E, Ben-Yosef T, Sharon D.   +17 more
europepmc   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Real-World outcomes of intravitreal treatment switching in retinal diseases: Analysis of 3,038 treated cases. [PDF]

Eur J Ophthalmol
Horozoglu Ceran T, Jabbarova G, Yokus R, Akdogan M, Dogan M.   +4 more
europepmc   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Lipid homeostasis plays a critical role in inherited and acquired retinal diseases. [PDF]

Commun Biol
Bhattacharyya A, Choudhary V.
europepmc   +1 more source

Zebrafish inversin mutants develop scoliosis in the absence of laterality defects

Developmental Dynamics, EarlyView.
Abstract Background Human mutations in INVERSIN are associated with nephronophthisis, variable penetrance of situs inversus and congenital heart disease. Inversin has been shown to localize to cilia and many of the patient phenotypes are attributed to disrupted cilia function.
Christopher J. Derrick, Lorraine Eley, Deborah J. Henderson, Bill Chaudhry   +3 more
wiley   +1 more source

Nanocarrier-Based Ocular Drug Delivery Systems for Retinal Diseases: Therapeutic Potential. [PDF]

Life (Basel)
Skarbek D, Sochocka A, Sidło O, Sapiaszko A, Drab A, Baj J, Rejdak R, Dolar-Szczasny J.   +7 more
europepmc   +1 more source

Loss of POGLUT2/3‐mediated O‐glucosylation produces lung and aortic phenotypes reminiscent of fibrillin1 mutants

Developmental Dynamics, EarlyView.
Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane, Angelina Almiroudis, Kaitlyn E. Donnelly, Robert S. Haltiwanger, Bernadette C. Holdener   +4 more
wiley   +1 more source