Aging, 2021 The cause of age-related macular degeneration (AMD) is unknown, but evidence indicates that both innate and adaptive immunity play a role in the pathogenesis. Our recent work has investigated AMD in patients with myeloproliferative neoplasms (MPNs) since
Charlotte Liisborg +4 more
semanticscholar +1 more source
TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis [PDF]
, 2015 Truncating mutations in the tumor suppressor gene adenomatous polyposis coli (APC) are the initiating step in the vast majority of sporadic colorectal cancers, and they underlie familial adenomatous polyposis (FAP) syndromes.
Creytens, David +8 more
core +5 more sources
Multimodal imaging of a sporadic retinal astrocytic hamartoma simulating retinoblastoma in a newborn
GMS Ophthalmology Cases, 2022 Objective: To report a sporadic astrocytic hamartoma simulating retinoblastoma in a newborn.Methods: Clinical data was reviewed retrospectively.Results: A 3-month-old baby with a history of perinatal asphyxia was referred to our ocular oncology clinic ...
Batu Oto, Bilge +3 more
doaj +1 more source
Identification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction. [PDF]
PLoS ONE, 2011 Paraneoplastic retinopathy (PR), including cancer-associated retinopathy (CAR) and melanoma-associated retinopathy (MAR), is a progressive retinal disease caused by antibodies generated against neoplasms not associated with the eye.
Mineo Kondo +10 more
doaj +1 more source
CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis [PDF]
, 2016 Retinoblastoma is a pediatric eye tumor in which bi-allelic inactivation of the Retinoblastoma 1 (RB1) gene is the initiating genetic lesion. Although recently curative rates of retinoblastoma have increased, there are at this time no molecular targeted ...
Boel, Annekatrien +12 more
core +2 more sources
Radiation retinopathy in patients treated for sinus and epipharingeal malignancies [PDF]
Vojnosanitetski Pregled, 2005 Background. Radiation retinopathy is vasculopathy induced by ionising radiation delivered by either brachytherapy or teletherapy for ocular and nonocular malignancies.
Kosanović-Jaković Natalija +3 more
doaj +1 more source
Imaging of adult ocular and orbital pathology - a pictorial review [PDF]
, 2014 Orbital pathology often presents a diagnostic challenge to the reporting radiologist. The aetiology is protean, and clinical input is therefore often necessary to narrow the differential diagnosis.
Brennan, Paul +8 more
core +1 more source
Red Blood Cells: Tethering, Vesiculation, and Disease in Micro-Vascular Flow
Diagnostics, 2021 The red blood cell has become implicated in the progression of a range of diseases; mechanisms by which red cells are involved appear to include the transport of inflammatory species via red cell-derived vesicles.
Robert J. Asaro, Pedro Cabrales
doaj +1 more source
A partial gene deletion of SLC45A2 causes oculocutaneous albinism in Doberman pinscher dogs. [PDF]
PLoS ONE, 2014 The first white Doberman pinscher (WDP) dog was registered by the American Kennel Club in 1976. The novelty of the white coat color resulted in extensive line breeding of this dog and her offspring.
Paige A Winkler +6 more
doaj +1 more source
The cell of origin dictates the temporal course of neurofibromatosis-1 (Nf1) low-grade glioma formation. [PDF]
, 2017 Low-grade gliomas are one of the most common brain tumors in children, where they frequently form within the optic pathway (optic pathway gliomas; OPGs).
Castillon, Guillaume A +9 more
core +3 more sources