Results 51 to 60 of about 654,251 (322)

The influence of DNA repair on neurological degeneration, cachexia, skin cancer and internal neoplasms: autopsy report of four xeroderma pigmentosum patients (XP-A, XP-C and XP-D) [PDF]

, 2013
BACKGROUND: To investigate the association of DNA nucleotide excision repair (NER) defects with neurological degeneration, cachexia and cancer, we performed autopsies on 4 adult xeroderma pigmentosum (XP) patients with different clinical features and ...
Alimchandani, Meghna, Aung, Phyu Phyu, Digiovanna, John J, Fine, Howard A, Hewitt, Stephen, Khan, Sikandar G, Kleiner, David E, Kraemer, Kenneth H, Lai, Jin-Ping, Lee, Chyi-Chia R, Levens, David L, Liu, Qingyan, Liu, Yen-Chun, Matsuda, Kant, Oberholtzer, J Carl, Patronas, Nicholas, Quezado, Martha M, Rushing, Elisabeth J, Tamura, Deborah, Tsokos, Maria   +19 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Ocular Toxicity Associated with Tamoxifen Administration in Patients with Breast Cancer: A Systematic Review [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Tamoxifen (TAM), a selective Oestrogen Receptor (ER) modulator, is widely used for treating and preventing ER-positive Breast Cancer (BC). TAM, administered as an adjuvant therapy for hormone receptor-positive BC, reduces recurrence but can
Tejaswi Vadde, Neha Narayan, Amulya Varshini Banka, Shravani Divity, Yethindra Vityala   +4 more
doaj   +1 more source

Two cases of uveitis masquerade syndrome caused by bilateral intraocular large B-cell lymphoma [PDF]

, 2013
Introduction. Sometimes it is not easy to clinically recognize subtle differences between intraocular lymphoma and noninfectious uveitis. The most common lymphoma subtype involving the eye is B-cell lymphoma. Case report.
Jovanović Svetlana, Jovanović Zorica, Marković Vujica, Paović Jelena, Pešić Snežana, Čeperković-Stanković Vesna   +5 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Adipose-derived mesenchymal stem cells (AdMSC) for the treatment of secondary-progressive multiple sclerosis: A triple blinded, placebo controlled, randomized phase I/II safety and feasibility study [PDF]

, 2018
Background Currently available treatments for secondary progressive multiple sclerosis(SPMS) have limited efficacy and/or safety concerns. Adipose-mesenchymal derived stem cells(AdMSCs) represent a promising option and can be readily obtained using ...
Fernández Montesinos, Rafael, Fernández, Oscar, Izquierdo Ayuso, Guillermo, Leyva, Laura, Pozo Pérez, David   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Mendelian randomization case-control PheWAS in UK Biobank shows evidence of causality for smoking intensity in 28 distinct clinical conditions

EClinicalMedicine, 2020
Background: Smoking is one of the greatest threats to public health worldwide. We integrated phenome-wide association study (PheWAS) and Mendelian randomization (MR) approaches to explore causal effects of genetically predicted smoking intensity across ...
Catherine King, Anwar Mulugeta, Farhana Nabi, Robert Walton, Ang Zhou, Elina Hyppönen   +5 more
doaj   +1 more source

Hyperpigmented spots at fundus examination: a new ocular sign in Neurofibromatosis Type I

Orphanet Journal of Rare Diseases, 2021
Background Neurofibromatosis Type I (NF1), also termed von Recklinghausen disease, is a rare genetic disorder that is transmitted by autosomal dominant inheritance, with complete penetrance and variable expressivity.
Antonietta Moramarco, Fabiana Mallone, Marta Sacchetti, Luca Lucchino, Emanuele Miraglia, Vincenzo Roberti, Alessandro Lambiase, Sandra Giustini   +7 more
doaj   +1 more source

Salivary gland neoplasms

The Indian journal of medical research, 2018
OCT angiography and have provided the evidence for paracentral acute middle maculopathy. The chapter on macular telangiectasia discusses the superiority of OCT angiography over other imaging techniques including FA and autofluorescence in this disease ...
A. Kamath
semanticscholar   +1 more source