Results 41 to 50 of about 17,845 (250)

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

Laser Retinotomy with “Ultra Q Reflex” System for the Prevention of Rhegmatogenous Retinal Detachment due to the Peripheral Horseshoe Tears

Oftalʹmologiâ, 2018
Purpose. To evaluate laser retinotomy efficacy in the retinal detachment (RD) due horseshoe tear prevention. Patients and methods. 57 eyes of 54 patients with subclinical retinal detachment due to the peripheral horseshoe retinal tear were enrolled.
A. V. Doga, P. L. Volodin, L. A. Kryl, Y. E. Yanilkina, D. A. Buryakov   +4 more
doaj   +1 more source

Morphofunctional retinal pigment epithelium changes in normal eye and age-related macular degeneration

Офтальмохирургия, 2023
Relevance. The retinal pigment epithelium performs a number of highly specialized functions. The relevance of studying morphological changes in the pigment epithelium is associated with an increased number of patients with age-related macular ...
R.R. Fayzrakhmanov, E.D. Bosov, V.A. Bogdanova, E.E. Vaganova, O.L. Sechina   +4 more
doaj   +1 more source

Shadow‐Calibrated Stereo Vision for Colorimetric Sweat Analysis

Advanced Science, EarlyView.
By establishing a mathematical model that reconstructs 3D structures through geometric features of object shadows under controlled illumination, and combining it with Convolutional Neural Network‐based 2D image analysis for volumetric calibration, this work enables highly accurate 3D morphological reconstruction.
Ting Xiao, Yuwen Yan, Miaorong Lin, Jiahui Chen, Jianxin Meng, Xiang Cui, Peng Zhang, Fengyu Li   +7 more
wiley   +1 more source

WS2 Optoelectronic Memristive Reservoir Enabling Ultra‐Low‐Power, Multi‐Task, and Environmentally Stable Neuromorphic Computing

Advanced Science, EarlyView.
WS2‐based in‐memory sensing reservoir computing integrates sensing, memory, and computation in one compact device. It achieves ∼94% N‐MNIST, ∼93% eye motion perception, and ∼89% speech recognition with ultra‐low energy (∼25.5 fJ/spike). The system shows stability at 95% humidity, endurance over 1.5M cycles, and supports synaptic plasticity, enabling ...
Dayanand Kumar, Hanrui Li, Divyanshu Divyanshu, Dhananjay D. Kumbhar, Manoj Kumar Rajbhar, Amit Singh, Abdul Momin Syed, Selma Amara, Gianluca Setti, Nazek El‐Atab   +9 more
wiley   +1 more source

The results of comparative analysis of angiogenic and laser therapy for diabetic macular edema in diabetes type 2

Oftalʹmologiâ, 2014
Purpose: To compare the results of laser treatment and intravitreal ranibizumab injections in patients with DME consistent with the level of VEGF A in tear fluid.Methods: The progress of visual acuity, retinal thickness and light sensivity after laser ...
I. V. Vorobieva, E. V. Parfenova, D. A. Merkushenkova, P. I. Makarevich, V. I. Alekhnovich   +4 more
doaj   +3 more sources

STUDIES OF SYSTEMIC AND LOCAL CYTOKINE LEVEL IN RETINAL VEIN OCCLUSION ASSOCIATED WITH ANTIANGIOGENIC THERAPY

Медицинская иммунология, 2018
The paper presents results of studying systemic and local level of cytokines in retinal vein occlusion following antiangiogenic therapy. The study of cytokine concentrations was conducted in the general group of patients, and depended on the type of ...
E. A. Drozdova, D. Yu. Khokhlova, E. A. Mezentseva, K. V. Nikushkina   +3 more
doaj   +1 more source

Optimizing Retinal Thermofusion in Retinal Detachment Repair

Ophthalmology Science, 2022
Purpose: Rhegmatogenous retinal detachment repair by intraoperative sealing of the tear without a tamponade agent should enable faster restoration of vision and resumption of normal activities.
Wilson J. Heriot, MB, BS, Andrew B. Metha, PhD, BScOptom, Zheng He, PhD, MSci, Jeremiah K.H. Lim, PhD, Anh Hoang, BSci, Tomoharu Nishimura, PhD, MD, Mali Okada, MBBS, Bang V. Bui, PhD, BSciOptom   +7 more
doaj   +1 more source