Results 271 to 280 of about 992,417 (341)

Synergistic inhibition of macular vascular permeability in diabetic edema: Ginsenoside Rg3 enhances ranibizumab efficacy by targeting angiopoietin‐like protein 4 and vascular endothelial growth factor via neuropilin/RhoA signaling

open access: yesJournal of Diabetes Investigation, Volume 17, Issue 5, Page 751-765, May 2026.
Molecular mechanism of synergistic antagonism of ANGPTL4 and VEGF by ginsenoside Rg3 combined with ranibizumab, regulating the NRP/RhoA pathway to inhibit macular edema. ABSTRACT Aims This study investigated the molecular mechanisms by which ginsenoside Rg3 combined with ranibizumab alleviates diabetic macular edema (DME), focusing on antagonizing ...
Jiexin Yu, Xingyu Li, Yanli Liu
wiley   +1 more source

Isolated Kidney Transplant in Primary Hyperoxaluria‐1 Enabled by Small Interfering RNA (siRNA) Therapy. Is It Time for Change? Case Report and Review of the Literature

open access: yesPediatric Transplantation, Volume 30, Issue 5, May 2026.
ABSTRACT Background Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder characterized by excessive oxalate production that leads to nephrocalcinosis or nephrolithiasis and progressive kidney failure, associated with systemic oxalosis that is not reversed by dialysis. Pharmacological treatment is limited.
Shameer M. Habeeb   +8 more
wiley   +1 more source

Oxygen diffusion kinetics, buffering capacity and phenotype: A narrative review of oxygen physiology and later phenotype in very preterm infants

open access: yesExperimental Physiology, Volume 111, Issue 5, Page 2485-2493, 1 May 2026.
Abstract Clinicians often view exposure to supplementary oxygen in preterm infants as a simple reciprocal trade‐off between mortality and the risk of vision‐threatening retinopathy, but this perspective oversimplifies the underlying physiology. Oxygen moves through a series of spatially distinct compartments without intrinsic regulation, with Fick's ...
Chad C Andersen   +3 more
wiley   +1 more source

Purification and Transcriptomic Characterization of Hypertrophied Hepatic Stellate Cells From CDAHFD Mouse Liver

open access: yesThe FASEB Journal, Volume 40, Issue 8, 30 April 2026.
The purification protocol for hypertrophied hepatic stellate cells (hypHSCs) developed in this study, using fibrotic and steatotic mouse livers (CDAHFD model), made it possible to obtain a high‐purity hypHSC preparation for transcriptomic analysis.
Marion Heckmann   +9 more
wiley   +1 more source

Unraveling causal pathways in retinal vein occlusion: a systematic review of Mendelian randomization studies. [PDF]

open access: yesInt J Retina Vitreous
Alamoudi A   +9 more
europepmc   +1 more source

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