Results 131 to 140 of about 76,093 (302)

Angiogenesis as a Therapeutic Target of (Poly)phenols: Tackling Cancer and Vascular‐Related Complications

open access: yesMolecular Nutrition &Food Research, EarlyView.
(Poly)phenols constitute a source of natural therapeutic molecules capable of targeting angiogenesis in different scenarios. This review summarizes the current evidence of the role of (poly)phenols in modulating angiogenesis. The reader can find a compilation of preclinical and human investigations describing pro‐ and anti‐angiogenic effects of these ...
María Ángeles Ávila‐Gálvez   +5 more
wiley   +1 more source

Experimental and Computational Insights into the Structural Dynamics of the Fc Fragment of IgG1 Subtype from Biosimilar VEGF‐Trap

open access: yesSmall Structures, EarlyView.
The constant fragment (Fc) of the immunoglobulin G1 (IgG1) subtype is a widely used scaffold for designing advanced therapeutics. Herein, together with the integration of experimental and computational techniques, this study reveals the structural dynamics of the N‐glycan‐bound Fc fragment of IgG1 from VEGF‐Trap, providing a new insight into enhancing ...
Ebru Destan   +11 more
wiley   +1 more source

VGA‐Net: Vessel graph based attentional U‐Net for retinal vessel segmentation

open access: yesIET Image Processing
Segmentation is crucial in diagnosing retinal diseases by accurately identifiying retinal vessels. This paper addresses the complexity of segmenting retinal vessels, highlighting the need for precise analysis of blood vessel structures.
Yeganeh Jalali   +2 more
doaj   +1 more source

Sphingosine‐1‐Phosphate Receptor Modulators for the Treatment of Ulcerative Colitis: A Narrative Review Focusing on Safety

open access: yesUnited European Gastroenterology Journal, EarlyView.
ABSTRACT Ulcerative colitis is a chronic immune‐mediated inflammatory disease of the colon that causes considerable morbidity and increases the risk of colorectal cancer. Several targeted therapies have been developed for moderate‐to‐severe ulcerative colitis, significantly improving its management.
Massimo C. Fantini   +4 more
wiley   +1 more source

A New Seeded Region Growing Technique for Retinal Blood Vessels Extraction

open access: yesJournal of Medical Signals and Sensors, 2014
Distribution of retinal blood vessels (RBVs) in retinal images has an important role in the prevention, diagnosis, monitoring and treatment of diseases, such as diabetes, high blood pressure, or heart disease.
Atefeh Sadat Sajadi   +1 more
doaj  

An (omics) perspective on the evolution of vision in deep‐sea fishes reveals exceptional adaptations to life in the extreme

open access: yesFunctional Ecology, EarlyView.
Abstract In the evolution of vision, changes in the number of visual opsin genes, gene conversion, amino acid sequence mutations, and gene expression levels are common molecular mechanisms in how teleost fishes adapt to different aquatic (light) environments.
Zuzana Musilova, Fabio Cortesi
wiley   +1 more source

The role of the host—Neutrophil biology

open access: yesPeriodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple   +4 more
wiley   +1 more source

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