Results 241 to 250 of about 141,412 (299)

Biallelic COL4A2 Variants Associated With Brain Small Vessel Disease and Brain Malformations

Clinical Genetics, EarlyView.
Biallelic COL4A2 variants cause a spectrum of brain abnormalities such as brain small vessel disease (BSVD). We describe two cases—one with cerebrovascular disruption and one with cortical malformations—expanding the recessive phenotype. Protein modeling reveals destabilization by p.(Arg179Cys), reinforcing its pathogenic role and highlighting collagen
Anees Muhammad, Mohammad Sadegh Shams Nosrati, Alireza Dostmohammadi, Reihaneh Khorasanian, Mariasavina Severino, Morteza Doustmohammadi, Francesca Madia, Siddharth Srivastava, Aisling Quinlan, Dario Paladini, Federico Zara, Marcello Scala   +11 more
wiley   +1 more source

Corkscrew retinal vessels and retinal arterial macroaneurysm in a patient with neurofibromatosis type 1: A case report. [PDF]

Medicine (Baltimore), 2018
Lu J, Liu H, Zhang L, Ma L, Zhou H.
europepmc   +1 more source

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms

Cell Proliferation, EarlyView.
Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng, Zuping Wu, Mengjie Wu, Liang Xie, Qianming Chen   +4 more
wiley   +1 more source

Changes in Relative Position of Choroidal Versus Retinal Vessels in Preterm Infants. [PDF]

Invest Ophthalmol Vis Sci, 2017
Kim SJ, Campbell JP, Ostmo S, Jonas KE, Chan RVP, Chiang MF, Imaging and Informatics in Retinopathy of Prematurity (i-ROP) Research Consortium.   +6 more
europepmc   +1 more source

Safety and efficacy of the therapy with CD4 + CD25highCD127‐T regulatory cells: When paediatric patient becomes adult

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aim CD4 + CD25highCD127‐T regulatory cells (Tregs) remain a drug candidate for immunotherapy of type 1 diabetes. We completed three trials testing Tregs in recently diagnosed type 1 diabetes children. Here, we looked for long‐term safety and efficacy aspects important in the authorisation of this therapy.
Marta Bandura, Magdalena Piotrowska‐Mieczkowska, Matylda Hennig, Mateusz Gliwiński, Anna Wołoszyn‐Durkiewicz, Julia Schoenhoff, Milena Dybowska, Anna Alska, Piotr Gutknecht, Bartosz Trzeciak, Katarzyna Stefańska, Paulina Glasner, Marcin Hellmann, Jacek Burzyński, Arkadiusz Michalak, Janusz Siebert, Dorota Iwaszkiewicz‐Grześ, Małgorzata Myśliwiec, Piotr Trzonkowski   +18 more
wiley   +1 more source

Contrast Agent Enhanced Multimodal Photoacoustic Microscopy and Optical Coherence Tomography for Imaging of Rabbit Choroidal and Retinal Vessels in vivo. [PDF]

Sci Rep, 2019
Nguyen VP, Li Y, Qian W, Liu B, Tian C, Zhang W, Huang Z, Ponduri A, Tarnowski M, Wang X, Paulus YM.   +10 more
europepmc   +1 more source

A matter arising: When should inflammatory and autoimmune rheumatic diseases be considered ‘early’?

European Journal of Clinical Investigation, EarlyView.
Timely recognition of inflammatory and autoimmune rheumatic diseases (IARDs) is important to optimize the early diagnosis with tailored interventions and possible prevention of irreversible organ damage. This narrative review provides an update by summarizing the advances in identifying the early stages of rheumatoid arthritis, systemic sclerosis and ...
Elvis Hysa, Emanuele Gotelli, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Vanessa Smith, Rosanna Campitiello, Maurizio Cutolo   +7 more
wiley   +1 more source

Examining the Role of Artificial Intelligence in Assessment: A Comparative Study of ChatGPT and Educator‐Generated Multiple‐Choice Questions in a Dental Exam

European Journal of Dental Education, EarlyView.
ABSTRACT Aim To compare the item difficulty and discriminative index of multiple‐choice questions (MCQs) generated by ChatGPT with those created by dental educators, based on the performance of dental students in a real exam setting. Materials and Methods A total of 40 MCQs—20 generated by ChatGPT 4.0 and 20 by dental educators—were developed based on ...
Nezaket Ezgi Özer, Yusuf Balcı, Gaye Bölükbaşı, Betul İlhan, Pelin Güneri   +4 more
wiley   +1 more source

The effect of vitreomacular and cataract surgery on oxygen saturation in retinal vessels. [PDF]

Clin Ophthalmol, 2017
Nakano Y, Manabe K, Osaka R, Takasago Y, Ono A, Kobayashi M, Fujita T, Shiragami C, Hirooka K, Tsujikawa A.   +9 more
europepmc   +1 more source