Results 131 to 140 of about 57,799 (256)

An Evaluation of Foreign Clinical Data in the Approval Reviews of Antimicrobial Medicines in Japan: Considering Ethnic and Regional Differences in Data Extrapolations in Accordance With Regulatory Circumstances

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT The approval requirements in new regions that do not require domestic clinical data and the clinical data evaluation of multi‐regional clinical trials (MRCTs) and foreign clinical trials (FCTs) in the Japanese approval review processes for antimicrobial medicines were explored.
Rumiko Shimazawa, Masayuki Ikeda
wiley   +1 more source

Murine Cytomegalovirus and Human Cytomegalovirus Differ in Pyroptosis Induction in Different Cell Types During Productive Replication

open access: yesViruses
Pyroptosis is a proinflammatory programmed cell death (PCD) that protects the host against invading viruses. We previously reported that pyroptosis plays a prominent role in the pathogenesis of murine cytomegalovirus (MCMV) retinal necrosis using mice ...
Jessica J. Carter   +3 more
doaj   +1 more source

Roles of ER Membrane Protein Complex in Protein Biogenesis and Quality Control in the Lung and Beyond

open access: yesCell Proliferation, Volume 59, Issue 6, June 2026.
The endoplasmic reticulum membrane protein complex (EMC) is an evolutionarily conserved, multi‐subunit transmembrane protein complex crucial to membrane protein biogenesis and cellular protein quality control. This review systematically examines the structure, functions and disease‐associated regulatory mechanisms of EMC across multiple organ systems ...
Yan Qiao   +6 more
wiley   +1 more source

Application of a Laser Flare-Cell Meter to Examine Blood-Aqueous Barrier Function in a Patient with Retinitis Punctata Albescens

open access: yes, 2009
A laser flare-cell meter was used to examine blood-aqueous barrier function in a 21-year-old male patient who had typical retinitis punctata albescens with white dots scattered throughout large areas of the fundus in both eyes.
陳慕師;張慶忠;方怡謨;鄭敏蟬;侯平康   +1 more
core  

Next‐Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS

open access: yesCell Proliferation, Volume 59, Issue 6, June 2026.
Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang   +8 more
wiley   +1 more source

Retinitis Pigmentosa

open access: yes, 1971
Presenting Symptom: Visual field constriction. Pathology: Pigmentary retinopathy. Clinical: Although occurring usually as a solitary entity, retinitis pigmentosa may be associated with several systemic hereditary conditions: deafness, cerebellar ...
David G. Cogan, MD (1908-1993)
core  

Treatment of cytomegalovirus retinitis

open access: yes, 2019
Cytomegalovirus retinitis is an inflammatory necrotic disease of the retina that can have a rapidly progressing course. Patients suffering from acquired immunodeficiency syndrome and recipients of organs or hematopoietic stem cells are most susceptible ...
B. S. Pershin   +2 more
core   +1 more source

Serological screening for cytomegalovirus in a leucodepleted blood supply: A systematic review

open access: yesVox Sanguinis, Volume 121, Issue 6, Page 722-731, June 2026.
Abstract Background and Objectives Cytomegalovirus (CMV) causes harm in at‐risk populations. Selection of seronegative donors has been used to prevent transmission. Leucodepletion reduces the potential for CMV transmission; however, the residual risk is uncertain, leading to variability in practice.
Philip J. Crispin   +7 more
wiley   +1 more source

A case of bilateral presumed chikungunya neuroretinitis

open access: yesIndian Journal of Ophthalmology, 2009
Chikungunya fever is a relatively rare from of vector-borne viral fever caused by chikungunya virus and spread by bites of the Aedes aegypti and Aedes albopictus mosquito.
Mahesh G   +4 more
doaj  

Novel codon 15 RHO gene mutation associated with retinitis pigmentosa

open access: yes, 2018
 Manuel AP Vilela,1 Roberta K Menna Barreto,2 Pedro K Menna Barreto,1 Juliana MF Sallum,3 Vanessa S Mattevi1 1Department of Ophthalmology, Federal Health Sciences University of Porto Alegre, Porto Alegre, Brazil; 2Medical School, Federal University ...
Mattevi VS   +4 more
core  

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