Results 91 to 100 of about 60,185 (237)

Artificial intelligence‐quantified schisis volume as a structural endpoint for gene therapy clinical trials in X‐linked retinoschisis

Acta Ophthalmologica, EarlyView.
Abstract Purpose To use artificial intelligence (AI) for quantifying schisis volume (ASV) in X‐linked retinoschisis (XLRS) for use as a structural endpoint in gene therapy clinical trials. Methods We used data from Singapore, the United Kingdom, the Netherlands, and the United States. The AI model was developed on 250 optical coherence tomography (OCT)
Tien‐En Tan, Peilun Dai, Jonathan Hensman, Peter Kiraly, Beau J. Fenner, Yong Liu, Rick S. M. Goh, Ian C. Han, Daniel S. W. Ting, Camiel J. F. Boon, M. Dominik Fischer   +10 more
wiley   +1 more source

Evaluation of contrast visual acuity in patients with retinitis pigmentosa

Clinical Ophthalmology, 2011
Kazumi Oomachi1, Kazuha Ogata2, Takeshi Sugawara2, Akira Hagiwara2, Akira Hata1, Shuichi Yamamoto21Department of Public Health; 2Department of Ophthalmology, Chiba University Graduate School of Medicine, Chiba, JapanBackground: The purpose of this study ...
Oomachi K, Ogata K, Sugawara T, Hagiwara A, Hata A, Yamamoto S.   +5 more
doaj  

Construction of a plasmid for human brain-derived neurotrophic factor and its effect on retinal pigment epithelial cell viability

Neural Regeneration Research, 2016
Several studies have investigated the protective functions of brain-derived neurotrophic factor (BDNF) in retinitis pigmentosa. However, a BDNF-based therapy for retinitis pigmentosa is not yet available.
Bo-jing Yan, Zhi-zhong Wu, Wei-hua Chong, Gen-lin Li   +3 more
doaj   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, EarlyView.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

Effect of Oral Valproic Acid vs Placebo for Vision Loss in Patients With Autosomal Dominant Retinitis Pigmentosa: A Randomized Phase 2 Multicenter Placebo-Controlled Clinical Trial

JAMA ophthalmology, 2018
Importance There are no approved drug treatments for autosomal dominant retinitis pigmentosa, a relentlessly progressive cause of adult and childhood blindness.
D. Birch, P. Bernstein, Alessandro Iannacone, M. Pennesi, B. Lam, J. Heckenlively, K. Csaky, M. Hartnett, K. Winthrop, T. Jayasundera, D. Hughbanks-Wheaton, J. Warner, Paul Yang, G. Fish, M. Teske, Neal L Sklaver, Laura R. Erker, Elvira N. Chegarnov, Travis B. Smith, A. Wahle, P. Vanveldhuisen, J. McCormack, R. Lindblad, S. Bramer, S. Rose, P. Zilliox, P. Francis, R. Weleber   +27 more
semanticscholar   +1 more source

Validation of a deep learning model for the automated detection and quantification of cystoid macular oedema on optical coherence tomography in patients with retinitis pigmentosa

Acta Ophthalmologica, EarlyView.
Abstract Purpose Accurate assessment of cystoid macular oedema (CMO) in patients with retinitis pigmentosa (RP) on spectral‐domain optical coherence tomography (SD‐OCT) is crucial for tracking disease progression and may serve as a therapeutic endpoint. Manual CMO segmentation is labour‐intensive and prone to variability, making artificial intelligence
Hind Almushattat, Jonathan Hensman, Yasmine el Allali, Coen de Vente, Clara I. Sánchez, Camiel J. F. Boon   +5 more
wiley   +1 more source

Intraretinal hyperreflective foci on spectral-domain optical coherence tomographic images of patients with retinitis pigmentosa

Clinical Ophthalmology, 2014
Masako Kuroda,1 Yasuhiko Hirami,1–3 Masayuki Hata,4 Michiko Mandai,1–3 Masayo Takahashi,1–3 Yasuo Kurimoto1–3 1Department of Ophthalmology, Kobe City Medical Center General Hospital, 2Department of Ophthalmology, Institute of ...
Kuroda M, Hirami Y, Hata M, Mandai M, Takahashi M, Kurimoto Y   +5 more
doaj  

Photobiomodulation therapy as a new hope therapy for retinitis pigmentosa: a systematic review

Revista Brasileira de Oftalmologia
Retinitis pigmentosa is one of the leading causes of hereditary blindness in developed countries and unfortunately there is currently no cure. Photobiomodulation therapy can penetrate the retina and optic nerve and restore the function of damaged ...
Ivana Beatrice Alberta, Yufilia Suci Amelia, Airina Stefanie   +2 more
doaj   +1 more source

Presentation of Complex Homozygous Allele in ABCA4 Gene in a Patient with Retinitis Pigmentosa

Case Reports in Ophthalmological Medicine, 2015
Retinitis pigmentosa is a degenerative retinal disease characterized by progressive photoreceptor damage, which causes loss of peripheral and night vision and the development of tunnel vision and may result in loss of central vision. This study describes
Māreta Audere, Katrīna Rutka, Svetlana Šepetiene, Baiba Lāce   +3 more
doaj   +1 more source

Novel VAC14 Variants Identified in a Patient with Striatonigral Degeneration and Prolonged Survival

Movement Disorders Clinical Practice, EarlyView.
Silvestre Cuinat, Christèle Dubourg, Gaël Nicolas, Jean‐Madeleine de Sainte Agathe, Sylvie Odent, Laurent Pasquier, Audrey Riou   +6 more
wiley   +1 more source