Results 101 to 110 of about 60,943 (273)

Evaluation of contrast visual acuity in patients with retinitis pigmentosa

Clinical Ophthalmology, 2011
Kazumi Oomachi1, Kazuha Ogata2, Takeshi Sugawara2, Akira Hagiwara2, Akira Hata1, Shuichi Yamamoto21Department of Public Health; 2Department of Ophthalmology, Chiba University Graduate School of Medicine, Chiba, JapanBackground: The purpose of this study ...
Oomachi K, Ogata K, Sugawara T, Hagiwara A, Hata A, Yamamoto S.   +5 more
doaj  

Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential for hypoxia-induced mitophagy through regulating ULK1 mRNA splicing

Autophagy, 2018
Aged and damaged mitochondria can be selectively degraded by specific autophagic elimination, termed mitophagy. Defects in mitophagy have been increasingly linked to several diseases including neurodegenerative diseases, metabolic diseases and other ...
Guang Xu, Tingting Li, Jiayi Chen, Changyan Li, Haixin Zhao, C. Yao, Hua Dong, Kaiqing Wen, Kai Wang, Jie Zhao, Qing Xia, Tao Zhou, Huafeng Zhang, P. Gao, Ailing Li, Xin Pan   +15 more
semanticscholar   +1 more source

Retinal remodeling in human retinitis pigmentosa

Experimental Eye Research, 2016
Retinitis Pigmentosa (RP) in the human is a progressive, currently irreversible neural degenerative disease usually caused by gene defects that disrupt the function or architecture of the photoreceptors. While RP can initially be a disease of photoreceptors, there is increasing evidence that the inner retina becomes progressively disorganized as the ...
Jones, B.W., Pfeiffer, R.L., Ferrell, W.D., Watt, C.B., Marmor, M., Marc, R.E.   +5 more
openaire   +3 more sources

Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases

British Journal of Pharmacology, EarlyView.
Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota, Theodora Calogeropoulou, Konstantina Chanoumidou, Ioannis Charalampopoulos, Achille Gravanis   +4 more
wiley   +1 more source

Intraretinal hyperreflective foci on spectral-domain optical coherence tomographic images of patients with retinitis pigmentosa

Clinical Ophthalmology, 2014
Masako Kuroda,1 Yasuhiko Hirami,1–3 Masayuki Hata,4 Michiko Mandai,1–3 Masayo Takahashi,1–3 Yasuo Kurimoto1–3 1Department of Ophthalmology, Kobe City Medical Center General Hospital, 2Department of Ophthalmology, Institute of ...
Kuroda M, Hirami Y, Hata M, Mandai M, Takahashi M, Kurimoto Y   +5 more
doaj  

Presentation of Complex Homozygous Allele in ABCA4 Gene in a Patient with Retinitis Pigmentosa

Case Reports in Ophthalmological Medicine, 2015
Retinitis pigmentosa is a degenerative retinal disease characterized by progressive photoreceptor damage, which causes loss of peripheral and night vision and the development of tunnel vision and may result in loss of central vision. This study describes
Māreta Audere, Katrīna Rutka, Svetlana Šepetiene, Baiba Lāce   +3 more
doaj   +1 more source

Construction of a plasmid for human brain-derived neurotrophic factor and its effect on retinal pigment epithelial cell viability

Neural Regeneration Research, 2016
Several studies have investigated the protective functions of brain-derived neurotrophic factor (BDNF) in retinitis pigmentosa. However, a BDNF-based therapy for retinitis pigmentosa is not yet available.
Bo-jing Yan, Zhi-zhong Wu, Wei-hua Chong, Gen-lin Li   +3 more
doaj   +1 more source

Cystoid Macular Edema Secondary to Hyperviscosity Syndrome in Waldenström Macroglobulinemia: A Case Report of Multimodal Treatment Response and the Adjunctive Role of Acetazolamide

The Kaohsiung Journal of Medical Sciences, EarlyView.
Yu‐Mei Yang, Chuan‐Cheng Wang, San‐Ni Chen, Jian‐Sheng Wu   +3 more
wiley   +1 more source

Decoding the Genetic Puzzle of Inherited Retinal Dystrophies: Novel Insights From a Turkish Cohort

Clinical Genetics, EarlyView.
This study analyzes 94 IRD patients from a Turkish cohort using a 141‐gene NGS panel, achieving a 74% diagnostic yield. The identification of 28 novel variants highlights the genetic diversity of IRDs in Türkiye and underscores the value of population‐specific molecular testing.
Şenol Demir, Esra Arslan Ateş, Orkun Sevik, Bengisu Sözer, Tuğba Köse, Özlem Şahin, Ahmet Arman, Bilgen Bilge Geçkinli   +7 more
wiley   +1 more source

Effect of Oral Valproic Acid vs Placebo for Vision Loss in Patients With Autosomal Dominant Retinitis Pigmentosa: A Randomized Phase 2 Multicenter Placebo-Controlled Clinical Trial

JAMA ophthalmology, 2018
Importance There are no approved drug treatments for autosomal dominant retinitis pigmentosa, a relentlessly progressive cause of adult and childhood blindness.
D. Birch, P. Bernstein, Alessandro Iannacone, M. Pennesi, B. Lam, J. Heckenlively, K. Csaky, M. Hartnett, K. Winthrop, T. Jayasundera, D. Hughbanks-Wheaton, J. Warner, Paul Yang, G. Fish, M. Teske, Neal L Sklaver, Laura R. Erker, Elvira N. Chegarnov, Travis B. Smith, A. Wahle, P. Vanveldhuisen, J. McCormack, R. Lindblad, S. Bramer, S. Rose, P. Zilliox, P. Francis, R. Weleber   +27 more
semanticscholar   +1 more source