Results 11 to 20 of about 87,753 (269)

Test–retest variability of the full‐field stimulus test in patients with retinitis pigmentosa: REPEAT Study Report No. 4 [PDF]

Acta Ophthalmologica, Volume 104, Issue 1, Page 89-97, February 2026.
Abstract Purpose To evaluate test–retest variability (TRV) of the full‐field stimulus test (FST) in patients with retinitis pigmentosa (RP) and poor best‐corrected visual acuity (BCVA; ≤20/50 Snellen; ≥0.40 logMAR), and to assess the reliability of FST as a clinical endpoint in future RP trials.
Jessica S. Karuntu, S. B. A. E. Tulp, Camiel J.F. Boon   +2 more
openalex   +2 more sources

Changes in Retinal Sensitivity Associated With Cotoretigene Toliparvovec in X-Linked Retinitis Pigmentosa With RPGR Gene Variations

JAMA ophthalmology, 2023
This post hoc analysis of the XIRIUS and XOLARIS studies investigates how changes in visual function associated with cotoretigene toliparvovec gene therapy in participants with RPGR-variant X-linked retinitis pigmentosa compare with those of untreated ...
Lenore Soodak von Krusenstiern, Jiajun Liu, Eileen Liao, J. Gow, Guo Chen, Tuyen Ong, A. Lotery, A. Jalil, B. Lam, R. MacLaren   +9 more
semanticscholar   +1 more source

Estimation of Visual Function Using Deep Learning From Ultra-Widefield Fundus Images of Eyes With Retinitis Pigmentosa

JAMA ophthalmology, 2023
Key Points Question Can artificial intelligence estimate the visual function of eyes with retinitis pigmentosa from ultra-widefield fundus images? Findings In this multicenter cross-sectional study of 1274 eyes of 695 patients with retinitis pigmentosa ...
Daisuke Nagasato, Takahiro Sogawa, Mao Tanabe, Hitoshi Tabuchi, Shogo Numa, A. Oishi, Hanako Ohashi Ikeda, A. Tsujikawa, Tadao Maeda, M. Takahashi, Nana Ito, Gen Miura, Terumi Shinohara, Mariko Egawa, Y. Mitamura   +14 more
semanticscholar   +1 more source

Retinitis Pigmentosa: Burden of Disease and Current Unmet Needs

Clinical Ophthalmology, 2022
Retinitis Pigmentosa (RP), a group of inherited retinal dystrophies characterised by progressive vision loss, is the leading cause of visual disability and blindness in subjects less than 60 years old. Currently incurable, therapy is aimed at restricting
Nancy Cross, Cécile van Steen, Y. Zegaoui, A. Satherley, Luigi Angelillo   +4 more
semanticscholar   +1 more source

TSPO Modulation Prevents Photoreceptor Degeneration and Produces Neuroprotective Effects in an Animal Model of Retinitis Pigmentosa. [PDF]

Cells
Corsi F, Castagnoli J, Galante A, Fabiano A, Nuti E, Piras AM, Taliani S, Piano I, Gargini C.   +8 more
europepmc   +3 more sources

Cone photoreceptor dysfunction in retinitis pigmentosa revealed by optoretinography

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Many blinding diseases afflict photoreceptors, specialized cells in the retina that capture and transduce light to initiate vision. Biomarkers that are sensitive to photoreceptor health are crucial for early detection and effective treatment
Ayoub Lassoued, Furu Zhang, K. Kurokawa, Yan Liu, Marcel T. Bernucci, J. Crowell, Donald T. Miller   +6 more
semanticscholar   +1 more source

Current and Future Treatment of Retinitis Pigmentosa

Clinical Ophthalmology, 2022
Retinitis Pigmentosa (RP) is a group of inherited retinal dystrophies (IRDs) characterised by progressive vision loss. Patients with RP experience a significant impact on daily activities, social interactions, and employment, reducing their quality of ...
Nancy Cross, Cécile van Steen, Y. Zegaoui, A. Satherley, Luigi Angelillo   +4 more
semanticscholar   +1 more source

Molecular Mechanisms Related to Oxidative Stress in Retinitis Pigmentosa

Antioxidants, 2021
Retinitis pigmentosa (RP) is an inherited retinopathy. Nevertheless, non-genetic biological factors play a central role in its pathogenesis and progression, including inflammation, autophagy and oxidative stress.
C. Gallenga, Maria Lonardi, S. Pacetti, S. Violanti, P. Tassinari, F. Di Virgilio, M. Tognon, P. Perri   +7 more
semanticscholar   +1 more source

Müller glial responses compensate for degenerating photoreceptors in retinitis pigmentosa

Experimental and Molecular Medicine, 2021
Photoreceptor degeneration caused by genetic defects leads to retinitis pigmentosa, a rare disease typically diagnosed in adolescents and young adults.
Yohei Tomita, Chenxi Qiu, Edward Bull, William Allen, Yumi Kotoda, Saswata Talukdar, Lois E. H. Smith, Z. Fu   +7 more
semanticscholar   +1 more source

Mutations in splicing factor genes are a major cause of autosomal dominant retinitis pigmentosa in Belgian families [PDF]

, 2017
Purpose : Autosomal dominant retinitis pigmentosa (adRP) is characterized by an extensive genetic heterogeneity, implicating 27 genes, which account for 50 to 70% of cases.
Casteels, Ingele, Claes, Charlotte, Coppieters, Frauke, De Baere, Elfride, De Jaegere, Sarah, de Ravel, Thomy, De Zaeytijd, Julie, Depasse, Fanny, Flipts, Helena, Fransen, Erik, Leroy, Bart, Roels, Dimitri, Van Camp, Guy, Van Cauwenbergh, Caroline, WALRAEDT, SOPHIE   +14 more
core   +15 more sources