Results 141 to 150 of about 2,652,154 (287)

The retinol-binding cavity in RBP and CRBP.

open access: yes, 2012
Ligand binding sites show as cartoon and transparent surface respectively. The binding site surface is illustrated by meshed colors according to the electrostatic potential. We show the binding cavity in different directions to facilitate the observation
Yu-Ru Zhang (166483)   +2 more
core   +1 more source

Cyclic Treatment With WIN 18,446, a Potential Male Contraceptive, is as Effective as Continuous Treatment for Suppression of Spermatogenesis in Mice

open access: yesAndrology, Volume 14, Issue 6, Page 1472-1478, September 2026.
ABSTRACT Background Retinoic acid plays a critical role in spermatogenesis during both spermatogonial differentiation and spermiation. Mice lacking enzymes that synthesize retinoic acid, Aldh1a1/1a2, in the testes are infertile. WIN 18,446 reversibly inhibits spermatogenesis by inhibiting ALDH1A1/1A2 and is a promising approach to male contraception ...
Jisun Paik   +3 more
wiley   +1 more source

Free Fatty Acids Carried by Lipoproteins: Revisiting the Overlooked Cargo

open access: yesActa Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT Free fatty acids (FFAs) are hydrophobic and therefore cannot enter the bloodstream at appreciable levels unless they are solubilized by FFA carriers. Albumin has been appreciated for years as the major FFA carrier, but it is not the only carrier.
Gregory C. Henderson   +2 more
wiley   +1 more source

Pharmacological activation of NO‐cGMP signalling attenuates metabolic dysfunction‐associated steatohepatitis

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 18, Page 5476-5495, September 2026.
Background and Purpose Metabolic dysfunction‐associated steatohepatitis (MASH) is linked to activation of hepatic stellate cells (HSCs) to α‐smooth muscle actin–positive myofibroblasts that produce collagen and proinflammatory cytokines. Quiescent HSCs express the NO‐cGMP signalling axis.
Krithika Rajeeth   +14 more
wiley   +1 more source

Physicochemical Quality and Chemical Safety of Commercial Wet Cat Food: Composition, Oxidation, Biogenic Amines, and Trace Elements

open access: yesJournal of Animal Physiology and Animal Nutrition, Volume 110, Issue 5, Page 663-673, September 2026.
ABSTRACT This study investigated the physicochemical characteristics and chemical safety of commercial wet cat foods marketed in Brazil. Twenty products labeled as beef, chicken and fish flavors were analyzed for proximate composition, pH, lipid and protein oxidation, biogenic amines, and essential and potentially toxic trace elements.
Marina Teixeira de Vries Mársico   +6 more
wiley   +1 more source

Effect of Dietary Vitamin A, Breed, and Kidney Function on the Onset of Urinary Vitamin A Excretion and the Vitamin A Transport Complex in Growing Dogs

open access: yesJournal of Animal Physiology and Animal Nutrition, Volume 110, Issue 5, Page 813-819, September 2026.
ABSTRACT Vitamin A (retinol and retinyl esters) is present in substantial amounts in the urine of healthy adult dogs, but the mechanisms affecting its excretion are poorly understood. To assess whether the onset of urinary vitamin A excretion is dependent on dietary vitamin A intake, breed, and/or parameters of kidney function, 48 puppies from two ...
Jens Raila   +2 more
wiley   +1 more source

Molecular Mechanism of Absorption, Transport and Metabolic Transformation of Astaxanthin in Aquatic Animals

open access: yesReviews in Aquaculture, Volume 18, Issue 4, September 2026.
This manuscript systematically elucidates the molecular mechanisms underlying absorption, transport, and metabolism of Astaxanthin in aquatic animals, through the analysis of biological functions, transport proteins, and enzyme metabolism system. Furthermore, it outlines future molecular research strategies for Astaxanthin, providing a theoretical ...
Huakang Peng   +12 more
wiley   +1 more source

Last Tile Added to a Mosaic: Phylogenetic Placement of Enigmatic Freshwater Fish Leucalburnus satunini (Cypriniformes: Leuciscidae) Uncovered

open access: yesZoologica Scripta, Volume 55, Issue 5, Page 718-727, September 2026.
ABSTRACT Subfamily Leuciscinae, the largest freshwater fish group of the western Palearctic region, has been widely studied, including the phylogenetic relationships between its species and genera. However, until now, one genus completely escaped attention in this regard. Even though several works hypothesised about its evolutionary relationships based
Jasna Vukić   +3 more
wiley   +1 more source

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