Results 21 to 30 of about 21,717 (210)

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection

eLife, 2014
Retinol plays a vital role in the immune response to infection, yet proteins that mediate retinol transport during infection have not been identified.
Mehabaw G Derebe, Clare M Zlatkov, Sureka Gattu, Kelly A Ruhn, Shipra Vaishnava, Gretchen E Diehl, John B MacMillan, Noelle S Williams, Lora V Hooper   +8 more
doaj   +1 more source

Lower fetuin-A, retinol binding protein 4 and several metabolites after gastric bypass compared to sleeve gastrectomy in patients with type 2 diabetes. [PDF]

PLoS ONE, 2014
BACKGROUND: Bypass of foregut secreted factors promoting insulin resistance is hypothesized to be one of the mechanisms by which resolution of type 2 diabetes (T2D) follows roux-en-y gastric bypass (GBP) surgery.
Mia Jüllig, Shelley Yip, Aimin Xu, Greg Smith, Martin Middleditch, Michael Booth, Richard Babor, Grant Beban, Rinki Murphy   +8 more
doaj   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Vitamin A transport in plasma of the non-mammalian vertebrates: isolation and partial characterization of piscine retinol-binding protein1

Journal of Lipid Research, 1977
Studies were conducted to explore vitamin A transport in the non-mammalian vertebrates, especially Pisces, Amphibia, and Reptilia, and to isolate and partially characterize piscine retinol-binding protein.
Y Shidoji, Y Muto
doaj   +1 more source

Exploiting Blood Transport Proteins as Carborane Supramolecular Vehicles for Boron Neutron Capture Therapy

Nanomaterials, 2023
Carboranes are promising agents for applications in boron neutron capture therapy (BNCT), but their hydrophobicity prevents their use in physiological environments.
Tainah Dorina Marforio, Edoardo Jun Mattioli, Francesco Zerbetto, Matteo Calvaresi   +3 more
doaj   +1 more source

Control by the brain of vitamin A homeostasis

iScience, 2023
Summary: Vitamin A is a micronutrient essential for vertebrate animals maintained in homeostatic balance in the body; however, little is known about the control of this balance.
Peter I. Imoesi, Cristian M. Olarte-Sánchez, Lorenzo Croce, William S. Blaner, Peter J. Morgan, Lora Heisler, Peter McCaffery   +6 more
doaj   +1 more source

Cellular retinoid-binding proteins in reginerating rat liver: demonstration of a novel cellular retinoid-binding protein.

Journal of Lipid Research, 1981
Changes in the levels of liver cellular aetinol- and retinoic acid-binding proteins were studied after partial (about 70%) hepatectomy for 14 days in the rat.
M Omori, Y Muto, T Nagao
doaj   +1 more source

New insights on the protein-ligand interaction differences between the two primary cellular retinol carriers[S]

Journal of Lipid Research, 2010
The main retinol carriers in the cytosol are the cellular retinol-binding proteins types I and II (CRBP-I and CRBP-II), which exhibit distinct tissue distributions.
Lorella Franzoni, Davide Cavazzini, Gian Luigi Rossi, Christian Lücke   +3 more
doaj   +1 more source

Retinol Binding Protein [PDF]

Journal of Parenteral and Enteral Nutrition, 2011
Introduction: Burn injury leads to vast changes in both metabolic and inflammatory responses and is associated with increased morbidity and mortality. Insulin resistance (IR) and hyperglycemia are major components of the hypermetabolic response found in burn‐injured patients and subsequently contribute to adverse outcomes.
Robert, Kraft, David N, Herndon, Gabriela A, Kulp, Gabriel A, Mecott, Heiko, Trentzsch, Marc G, Jeschke   +5 more
openaire   +2 more sources