Results 41 to 50 of about 21,720 (214)

Genus-level evolutionary relationships of FAR proteins reflect the diversity of lifestyles of free-living and parasitic nematodes

BMC Biology, 2021
Background Nematodes are a widespread and diverse group comprising free-living and parasitic species, some of which have major detrimental effects on crops, animals, and human health. Genomic comparisons of nematodes may help reveal the genetic bases for
Dongjuan Yuan, Song Li, Ziyu Shang, Muchun Wan, Yu Lin, Yanhua Zhang, Yaoyu Feng, Lian Xu, Lihua Xiao   +8 more
doaj   +1 more source

Retinol-Binding Protein 4 in Human Obesity [PDF]

Diabetes, 2006
Studies in mice suggest that adipocytes serve as glucose sensors and regulate systemic glucose metabolism through release of serum retinol-binding protein 4 (RBP4). This model has not been validated in humans. RBP4 was highly expressed in isolated mature human adipocytes and secreted by differentiating human adipocytes.
Jürgen, Janke, Stefan, Engeli, Michael, Boschmann, Frauke, Adams, Jana, Böhnke, Friedrich C, Luft, Arya M, Sharma, Jens, Jordan   +7 more
openaire   +2 more sources

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

An insight into the changes in human plasma proteome on adaptation to hypobaric hypoxia. [PDF]

PLoS ONE, 2013
Adaptation to hypobaric hypoxia is required by animals and human in several physiological and pathological situations. Hypobaric hypoxia is a pathophysiological condition triggering redox status disturbances of cell organization leading, via oxidative ...
Yasmin Ahmad, Narendra K Sharma, Iti Garg, Mohammad Faiz Ahmad, Manish Sharma, Kalpana Bhargava   +5 more
doaj   +1 more source

Degradation Mechanisms, Encapsulation‐Based Stabilization, and Analytical Detection of Vitamin A

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Vitamin A is an important lipid‐soluble micronutrient essential for vision, immune function, and overall growth and development. However, vitamin A is unstable and susceptible to environmental factors because of its conjugated structure and inherent chemical reactivity.
Latheesha Abeywardana, Thambaramala V. Gamage, Tanoj K. Singh, Shuaifei Zhao, Amy Logan, Lingxue Kong   +5 more
wiley   +1 more source

Comparative proteomic analysis of gallbladder bile proteins related to cholesterol gallstones. [PDF]

PLoS ONE, 2013
BACKGROUND: Nucleation of cholesterol monohydrate crystals following the aggregation and fusion of cholesterol-enriched vesicles is a critical procedure in the formation of cholesterol gallstone. Biliary proteins play important roles in the process.
Diancai Zhang, Jianbin Xiang, Liying Wang, Zhibin Xu, Lidong Sun, Feng Zhou, Xiliang Zha, Duan Cai   +7 more
doaj   +1 more source

Pt‐TiO2 mesoporous nanosystem co‐delivering phlorezin enables synergistic sonodynamic‐chemoimmunotherapy for hepatocellular carcinoma via directly targeting DDX5 and metabolic reprogramming modulation

BMEMat, EarlyView.
Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu, Bo Zhang, Yue Wan, Zhiru Yang, Abdusami Abdurahman, Mengxin He, Shengtao Hu, Yi Zhang, Xiaoke Li, Jin Chang, Jun Kang, Liren Liu, Wanghua Liu, Shao Li   +13 more
wiley   +1 more source

Fatty acid-and retinol-binding protein, Mj-FAR-1 induces tomato host susceptibility to root-knot nematodes. [PDF]

PLoS ONE, 2013
Plant-parasitic nematodes produce at least one structurally unique class of small helix-rich retinol- and fatty-acid-binding proteins that have no counterparts in their plant hosts.
Ionit Iberkleid, Paulo Vieira, Janice de Almeida Engler, Kalia Firester, Yitzhak Spiegel, Sigal Brown Horowitz   +5 more
doaj   +1 more source

Mapping the interactions of dengue virus NS1 protein with human liver proteins using a yeast two-hybrid system: identification of C1q as an interacting partner. [PDF]

PLoS ONE, 2013
Dengue constitutes a global health concern. The clinical manifestation of this disease varies from mild febrile illness to severe hemorrhage and/or fatal hypovolemic shock.
Emiliana M Silva, Jonas N Conde, Diego Allonso, Mauricio L Nogueira, Ronaldo Mohana-Borges   +4 more
doaj   +1 more source

Vitamin A metabolism is changed in donors after living-kidney transplantation: an observational study

Lipids in Health and Disease, 2011
Background The kidneys are essential for the metabolism of vitamin A (retinol) and its transport proteins retinol-binding protein 4 (RBP4) and transthyretin.
Henze Andrea, Raila Jens, Kempf Caroline, Reinke Petra, Sefrin Anett, Querfeld Uwe, Schweigert Florian J   +6 more
doaj   +1 more source