Results 101 to 110 of about 2,652,210 (298)

Integrative Bioinformatics, Experimental Validation, and Interpretable Machine Learning Reveal Oxyresveratrol‐Mediated Protection Against Cadmium‐Induced Lung Adenocarcinoma‐Related Transcriptional Dysregulation

Environmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a toxic heavy metal strongly implicated in lung adenocarcinoma (LUAD) through mechanisms involving oxidative stress, epigenetic dysregulation, and chronic inflammation. This study aimed to identify Cd‐responsive genes associated with LUAD and to evaluate the protective effects of oxyresveratrol (O‐RES) against Cd‐induced ...
Murat Isıyel, Hamid Ceylan, Yeliz Demir
wiley   +1 more source

Functions of Intracellular Retinoid Binding-Proteins [PDF]

, 2016
Multiple binding and transport proteins facilitate many aspects of retinoid biology through effects on retinoid transport, cellular uptake, metabolism, and nuclear delivery.
Napoli, Joseph L, Joseph L. Napoli
core   +1 more source

Proteo-Metabolomic Profiling of PMM2-CDG Reveals Dysregulation of Retinoic Acid Synthesis, Myo-Inositol, and the Hexosamine Pathway. [PDF]

J Inherit Metab Dis
ABSTRACT Phosphomannomutase deficiency (PMM2‐CDG), the most common congenital disorder of glycosylation (CDG), is characterized by multisystem involvement and a lack of disease‐modifying therapies. While previous transcriptomic studies have uncovered disrupted cellular pathways, the functional consequences of these alterations remain poorly understood.
Gallego D, Andreotti G, Monticelli M, Paris D, Martín-Martínez A, Gámez A, Serrano M, Córdoba-Caballero J, Seoane P, Ranea JAG, Pérez B.   +10 more
europepmc   +2 more sources

The immunological landscape of the area postrema in neuromyelitis optica spectrum disorders

Brain Pathology, EarlyView.
Aquaporin‐4 antibody‐positive neuromyelitis spectrum disorder is characterized by large tissue destructive lesions in medulla, spinal cord, and optic nerves, with only partial recovery from clinical symptoms, and by lesions with very little tissue destruction and mostly complete recovery from clinical symptoms, as seen in the area postrema ...
Qian Yu, Yoshiki Takai, Naoya Yamazaki, Sarah Brandl, Katharina M. Mair, Thibault Bouderlique, Maria Eleni Kastriti, Igor Adameyko, Romana Höftberger, Markus Reindl, Jan Bauer, Monika Bradl   +11 more
wiley   +1 more source

Proteolysis of insulin-like growth factor binding proteins (IGFBPs) by calpain [PDF]

, 2005
Calpains are non-lysosomal, Ca2+-dependent cysteine proteases, which are ubiquitously distributed across cell types and vertebrate species. The rules that govern calpain specificity have not yet been determined.
Mann, Karlheinz, Mann, K., Ghosh, M., Machleidt, W., Machleidt, Werner, Siwanowicz, I., Ghosh, Madhumita, Holak, Tad A., Holak, T. A., Holak, T., Siwanowicz, Igor, Shanker, Sreejesh, Shanker, S.   +12 more
core   +1 more source

Histological manifestations of vitamin A toxicity in the liver

Histopathology, EarlyView.
Analysing clinicopathological data from 1960 to 2025, this study characterizes the spectrum of liver injury associated with chronic vitamin A toxicity. Hepatic stellate cell hypertrophy/hyperplasia and sinusoidal fibrosis emerge as the predominant features, providing a morphological basis for diagnosing vitamin A hepatotoxicity.
Giorgio Cazzaniga, Georg Lietz, Dina G. Tiniakos   +2 more
wiley   +1 more source

Retinol-Binding Protein Interferes with Transthyretin-Mediated β‑Amyloid Aggregation Inhibition

, 2018
β-Amyloid (Aβ) aggregation is causally linked to Alzheimer’s disease. On the basis of in vitro and transgenic animal studies, transthyretin (TTR) is hypothesized to provide neuroprotection against Aβ toxicity by binding to Aβ and inhibiting its ...
Regina M. Murphy, Regina M. Murphy (1553098), Parth Mangrolia, Parth Mangrolia (5578865)   +3 more
core   +1 more source

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

Versatile toolbox for high throughput biochemical and functional studies with fluorescent fusion proteins [PDF]

, 2012
Fluorescent fusion proteins are widely used to study protein localization and interaction dynamics in living cells. However, to fully characterize proteins and to understand their function it is crucial to determine biochemical characteristics such as ...
Sandra B. Hake (165089), Antonia Jack (165084), Sandra B Hake, Patricia Wolf, Pichler Garwin, Pichler, Garwin, Hake, Sandra B., Antonia Jack, Wolf Patricia, Garwin Pichler (165082), Jack Antonia, Wolf, Patricia, Jack, Antonia, Hake Sandra B., Garwin Pichler, Patricia Wolf (165088)   +15 more
core   +2 more sources

In vitro starch binding experiments: Study of the proteins related to grain hardness of wheat [PDF]

, 2007
Two friabilin components, puroindoline a and GSP-1 were expressed in Escherichia coli. Starch binding properties of the recombinant polypeptides and of friabilin extracted from wheat flour were compared in vitro. The produced proteins as well as native
Gardonyi, M., Bakó, Ambrus, Tamás, László   +2 more
core   +1 more source