Results 21 to 30 of about 1,339,271 (291)

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Characterisation of Bombyx mori odorant-binding proteins reveals that a general odorant-binding protein discriminates between sex pheromone components [PDF]

, 2009
In many insect species, odorant-binding proteins (OBPs) are thought to be responsible for the transport of pheromones and other semiochemicals across the sensillum lymph to the olfactory receptors (ORs) within the antennal sensilla.
Field, L.M., Pickett, J. A., Dufour, S. G. L., Zhou, J.J., Keep, N. H., Dufour, Samuel, Field, Linda M., He, X., Hooper, A.M., Hooper, A. M., Pickett, John A., Pickett, J.A., He, Xiaoli, Dufour, S., Field, L. M., Keep, Nicholas H., Robertson, G., Robertson, Giles, Zhou, J-J., Hooper, Antony M., Zhou, Jing-Jiang   +20 more
core   +1 more source

Solution structure of a repeated unit of the ABA-1 nematode polyprotein allergen of ascaris reveals a novel fold and two discrete lipid-binding sites [PDF]

, 2011
Parasitic nematode worms cause serious health problems in humans and other animals. They can induce allergic-type immune responses, which can be harmful but may at the same time protect against the infections. Allergens are proteins that trigger allergic
Ball, G., Smith, B.O., Cooper, Alan, Bromek Krystyna, Malcolm W Kennedy, Smith Brian O., Meenan, N.A.G., Bromek, K., Uhrín, D., Uhrin, Dusan, Cooper Alan, Brian O. Smith, Meenan, N., Krystyna Bromek, Bromek, Krystyna, Kennedy, M.W., Ball Graeme, Brian O Smith, Meenan, Nicola A. G., Alan Cooper, Uhrín Dušan, Cooper, A., Kennedy, M., Nicola A. G. Meenan, Malcolm W. Kennedy, Graeme Ball, Nicola A G Meenan, Kennedy, Malcolm W., Meenan Nicola A. G., Dušan Uhrín, Ball, Graeme, Kennedy Malcolm W., Smith, B., Smith, Brian O.   +33 more
core   +1 more source

Control by the brain of vitamin A homeostasis

iScience, 2023
Summary: Vitamin A is a micronutrient essential for vertebrate animals maintained in homeostatic balance in the body; however, little is known about the control of this balance.
Peter I. Imoesi, Cristian M. Olarte-Sánchez, Lorenzo Croce, William S. Blaner, Peter J. Morgan, Lora Heisler, Peter McCaffery   +6 more
doaj   +1 more source

Cellular retinoid-binding proteins in reginerating rat liver: demonstration of a novel cellular retinoid-binding protein.

Journal of Lipid Research, 1981
Changes in the levels of liver cellular aetinol- and retinoic acid-binding proteins were studied after partial (about 70%) hepatectomy for 14 days in the rat.
M Omori, Y Muto, T Nagao
doaj   +1 more source

RPB4 and pathogenesis of diabetes [PDF]

, 2007
Obesity is an important risk factor for a number of chronic diseases that impose a huge burden on individuals and society. Recently it has become clear that adipose tissue-secreted products may play a significant role in mediating many obesity-related ...
McTernan, P. G. (Philip G.), Kumar, Sudhesh   +1 more
core   +1 more source

New insights on the protein-ligand interaction differences between the two primary cellular retinol carriers[S]

Journal of Lipid Research, 2010
The main retinol carriers in the cytosol are the cellular retinol-binding proteins types I and II (CRBP-I and CRBP-II), which exhibit distinct tissue distributions.
Lorella Franzoni, Davide Cavazzini, Gian Luigi Rossi, Christian Lücke   +3 more
doaj   +1 more source

Retinol Binding Protein [PDF]

Journal of Parenteral and Enteral Nutrition, 2011
Introduction: Burn injury leads to vast changes in both metabolic and inflammatory responses and is associated with increased morbidity and mortality. Insulin resistance (IR) and hyperglycemia are major components of the hypermetabolic response found in burn‐injured patients and subsequently contribute to adverse outcomes.
Robert, Kraft, David N, Herndon, Gabriela A, Kulp, Gabriel A, Mecott, Heiko, Trentzsch, Marc G, Jeschke   +5 more
openaire   +2 more sources

Fluorine nuclear magnetic resonance analysis of the ligand binding properties of two homologous rat cellular retinol-binding proteins expressed in Escherichia coli.

Journal of Biological Chemistry, 1991
Comparative 19F NMR studies were performed on rat cellular retinol-binding protein (CRBP) and cellular retinol-binding protein II (CRBPII) to better understand their role in intracellular retinol metabolism within the polarized absorptive epithelial ...
E. Li, S. Qian, N. Winter, A. D'avignon, M. Levin, J. I. Gordon   +5 more
semanticscholar   +1 more source

Comparison of the tissue-specific expression and developmental regulation of two closely linked rodent genes encoding cytosolic retinol-binding proteins.

Journal of Biological Chemistry, 1987
Cellular retinol-binding protein (CRBP) and cellular retinol-binding protein II (CRBP II) are two highly homologous cytoplasmic proteins that bind all-trans-retinol. We have recently demonstrated that the mouse genes encoding CRBP and CRBP II are closely
M. Levin, E. Li, D. Ong, J. Gordon
semanticscholar   +1 more source