Results 151 to 160 of about 19,374 (236)

Pyruvate Kinase M2‐Mediated H3K9 Lactylation and XBP1 Signaling Positive Feedback Loop Facilitates CD4+ T Cell Spinal Recruitment and Central Sensitization in Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
In collagen‐induced arthritis (CIA) mice, increased CD4+ T cell accumulation in the spinal dorsal horn induces pain hypersensitivity. Mechanistically, PKM2‐mediated H3K9 lactylation and XBP1 signaling positive feedback loop facilitates CD4+ T cell spinal migration and induces central sensitization‐like behaviors in CIA mice.
Yuepeng Jiang   +10 more
wiley   +1 more source

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

open access: yesAdvanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng   +7 more
wiley   +1 more source

EHD‐LIFT: Electrohydrodynamic Laser Induced Forward Transfer

open access: yesAdvanced Science, EarlyView.
Electrohydrodynamic laser‐induced forward transfer (EHD‐LIFT) introduces electric field‐assisted control to LIFT. Through laser‐patterning a conductive absorber layer, local curvatures are induced in the donor film, enabling flow‐focusing for transfer of smaller droplets at lower laser energies.
Ankit Das   +5 more
wiley   +1 more source

Matrix Stiffness Promotes Tumor Metastasis by Triggering Recycling Endosome‐Mediated YY1 Nuclear Translocation and Transcriptional Activity

open access: yesAdvanced Science, EarlyView.
In stiff extracellular matrix (ECM), integrin αVβ3 transduces mechanical cues of ECM stiffness to promote recycling endosome formation, creating a signaling platform for yin yang 1 (YY1)/p21‐activated kinase 4 (PAK4) binding, but not in soft ECM. Then, this triggers PAK4‐mediated YY1 phosphorylation at S118, subsequent YY1 nuclear translocation and ...
Fuqiang Zhao   +7 more
wiley   +1 more source

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